evidence table

Hyaluronic Acid Skin Randomized Trial Evidence Table

Structured evidence table for Hyaluronic Acid Skin Randomized Trial, generated from 3 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Hyaluronic Acid Skin Randomized TrialIn accordance with EMA Committee for Advanced Therapies (EMA-CAT) recommendations (Guideline on Human Cell-Based Medicinal Products, 2015, section 2.2.4a), this approach qualifies as a “technique, since the processing does not alter the biological characteristics, physiological functions, or structural properties of the cells.2Gentile Pietro (2026)Autologous fibroblast therapy for facial rejuvenation: A randomized open-label controlled study
Hyaluronic Acid Skin Randomized Trial20 patients with mild to moderate dermal thinning, reduced elasticity, and wrinkles were assigned to the study group (SG) and treated with Am-FBs (A–C).2Gentile Pietro (2026)Autologous fibroblast therapy for facial rejuvenation: A randomized open-label controlled study
Hyaluronic Acid Skin Randomized TrialThe Risk Evaluation and Mitigation Strategies (REMSs) incorporating Elements to Assure Safe Use (ETASU) were applied in Am-FBs and HA-based skin booster treatments, significantly reducing safety-related risks.2Gentile Pietro (2026)Autologous fibroblast therapy for facial rejuvenation: A randomized open-label controlled study
Hyaluronic Acid Skin Randomized Trial, , , The natural aging process leads to the degradation of the dermal extracellular matrix (ECM), decreased fibroblast activity, and a loss of skin elasticity.Traditional cosmetic procedures, such as hyaluronic acid (HA)-based skin boosters, provide temporary benefits, but autologous cell-based therapies offer a biologically driven regenerative approach.2Gentile Pietro (2026)Autologous fibroblast therapy for facial rejuvenation: A randomized open-label controlled study
Hyaluronic Acid Skin Randomized TrialSome evidence also suggests that PAE may be related to stratum corneum impairment and insufficient skin hydration [].2Zhang Di (2026)Efficacy and Safety of Non‐Cross‐Linked Hyaluronic Acid Mesotherapy for Post‐Acne Erythema: A Split‐Face, Prospective, Randomized, Single‐Center Trial
Hyaluronic Acid Skin Randomized Trial[] demonstrated that intradermal injection of LMW‐HA significantly improved skin texture, reduced pores, and enhanced radiance.2Zhang Di (2026)Efficacy and Safety of Non‐Cross‐Linked Hyaluronic Acid Mesotherapy for Post‐Acne Erythema: A Split‐Face, Prospective, Randomized, Single‐Center Trial
Hyaluronic Acid Skin Randomized Trial1 2 3 1 Acne is a common chronic inflammatory skin disorder primarily of the pilosebaceous units [], affecting up to 85% of adolescents globally [].2Zhang Di (2026)Efficacy and Safety of Non‐Cross‐Linked Hyaluronic Acid Mesotherapy for Post‐Acne Erythema: A Split‐Face, Prospective, Randomized, Single‐Center Trial
Hyaluronic Acid Skin Randomized TrialAlthough primary acne lesions often resolve with treatment [], many patients may develop clinical sequelae following the resolution of inflammatory papules or pustules.2Zhang Di (2026)Efficacy and Safety of Non‐Cross‐Linked Hyaluronic Acid Mesotherapy for Post‐Acne Erythema: A Split‐Face, Prospective, Randomized, Single‐Center Trial
Hyaluronic Acid Skin Randomized TrialAccording to Merz scores before and 3 months after treatment, the wrinkles were dramatically reduced in both groups ( p value: p value: 0.633).2Saffarian Z (2026)Combined Use of Botulinum Toxin A and Profhilo for Upper Face Rejuvenation: A Randomized Clinical Trial.
Hyaluronic Acid Skin Randomized TrialConclusion We have shown that adding Profhilo to BTX-A injection does not have any short-term clinical or sonographic advantage in frontal area wrinkle reduction.2Saffarian Z (2026)Combined Use of Botulinum Toxin A and Profhilo for Upper Face Rejuvenation: A Randomized Clinical Trial.
Hyaluronic Acid Skin Randomized TrialBackground Hyaluronic acid (HA) and Botulinum toxin A (BTX-A) treatments are highly regarded for their effectiveness in facial rejuvenation.2Saffarian Z (2026)Combined Use of Botulinum Toxin A and Profhilo for Upper Face Rejuvenation: A Randomized Clinical Trial.
Hyaluronic Acid Skin Randomized TrialAim To investigate whether adding Profhilo enhances the effects of BTX-A for frontal skin rejuvenation.2Saffarian Z (2026)Combined Use of Botulinum Toxin A and Profhilo for Upper Face Rejuvenation: A Randomized Clinical Trial.
topicHyaluronic Acid Skin Randomized Trial
claimIn accordance with EMA Committee for Advanced Therapies (EMA-CAT) recommendations (Guideline on Human Cell-Based Medicinal Products, 2015, section 2.2.4a), this approach qualifies as a “technique, since the processing does not alter the biological characteristics, physiological functions, or structural properties of the cells.
evidence level2
citationGentile Pietro (2026)
sourceAutologous fibroblast therapy for facial rejuvenation: A randomized open-label controlled study
topicHyaluronic Acid Skin Randomized Trial
claim20 patients with mild to moderate dermal thinning, reduced elasticity, and wrinkles were assigned to the study group (SG) and treated with Am-FBs (A–C).
evidence level2
citationGentile Pietro (2026)
sourceAutologous fibroblast therapy for facial rejuvenation: A randomized open-label controlled study
topicHyaluronic Acid Skin Randomized Trial
claimThe Risk Evaluation and Mitigation Strategies (REMSs) incorporating Elements to Assure Safe Use (ETASU) were applied in Am-FBs and HA-based skin booster treatments, significantly reducing safety-related risks.
evidence level2
citationGentile Pietro (2026)
sourceAutologous fibroblast therapy for facial rejuvenation: A randomized open-label controlled study
topicHyaluronic Acid Skin Randomized Trial
claim, , , The natural aging process leads to the degradation of the dermal extracellular matrix (ECM), decreased fibroblast activity, and a loss of skin elasticity.Traditional cosmetic procedures, such as hyaluronic acid (HA)-based skin boosters, provide temporary benefits, but autologous cell-based therapies offer a biologically driven regenerative approach.
evidence level2
citationGentile Pietro (2026)
sourceAutologous fibroblast therapy for facial rejuvenation: A randomized open-label controlled study
topicHyaluronic Acid Skin Randomized Trial
claimSome evidence also suggests that PAE may be related to stratum corneum impairment and insufficient skin hydration [].
evidence level2
citationZhang Di (2026)
sourceEfficacy and Safety of Non‐Cross‐Linked Hyaluronic Acid Mesotherapy for Post‐Acne Erythema: A Split‐Face, Prospective, Randomized, Single‐Center Trial
topicHyaluronic Acid Skin Randomized Trial
claim[] demonstrated that intradermal injection of LMW‐HA significantly improved skin texture, reduced pores, and enhanced radiance.
evidence level2
citationZhang Di (2026)
sourceEfficacy and Safety of Non‐Cross‐Linked Hyaluronic Acid Mesotherapy for Post‐Acne Erythema: A Split‐Face, Prospective, Randomized, Single‐Center Trial
topicHyaluronic Acid Skin Randomized Trial
claim1 2 3 1 Acne is a common chronic inflammatory skin disorder primarily of the pilosebaceous units [], affecting up to 85% of adolescents globally [].
evidence level2
citationZhang Di (2026)
sourceEfficacy and Safety of Non‐Cross‐Linked Hyaluronic Acid Mesotherapy for Post‐Acne Erythema: A Split‐Face, Prospective, Randomized, Single‐Center Trial
topicHyaluronic Acid Skin Randomized Trial
claimAlthough primary acne lesions often resolve with treatment [], many patients may develop clinical sequelae following the resolution of inflammatory papules or pustules.
evidence level2
citationZhang Di (2026)
sourceEfficacy and Safety of Non‐Cross‐Linked Hyaluronic Acid Mesotherapy for Post‐Acne Erythema: A Split‐Face, Prospective, Randomized, Single‐Center Trial
topicHyaluronic Acid Skin Randomized Trial
claimAccording to Merz scores before and 3 months after treatment, the wrinkles were dramatically reduced in both groups ( p value: p value: 0.633).
evidence level2
citationSaffarian Z (2026)
sourceCombined Use of Botulinum Toxin A and Profhilo for Upper Face Rejuvenation: A Randomized Clinical Trial.
topicHyaluronic Acid Skin Randomized Trial
claimConclusion We have shown that adding Profhilo to BTX-A injection does not have any short-term clinical or sonographic advantage in frontal area wrinkle reduction.
evidence level2
citationSaffarian Z (2026)
sourceCombined Use of Botulinum Toxin A and Profhilo for Upper Face Rejuvenation: A Randomized Clinical Trial.
topicHyaluronic Acid Skin Randomized Trial
claimBackground Hyaluronic acid (HA) and Botulinum toxin A (BTX-A) treatments are highly regarded for their effectiveness in facial rejuvenation.
evidence level2
citationSaffarian Z (2026)
sourceCombined Use of Botulinum Toxin A and Profhilo for Upper Face Rejuvenation: A Randomized Clinical Trial.
topicHyaluronic Acid Skin Randomized Trial
claimAim To investigate whether adding Profhilo enhances the effects of BTX-A for frontal skin rejuvenation.
evidence level2
citationSaffarian Z (2026)
sourceCombined Use of Botulinum Toxin A and Profhilo for Upper Face Rejuvenation: A Randomized Clinical Trial.

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Source documents

  1. Autologous fibroblast therapy for facial rejuvenation: A randomized open-label controlled study
  2. Efficacy and Safety of Non‐Cross‐Linked Hyaluronic Acid Mesotherapy for Post‐Acne Erythema: A Split‐Face, Prospective, Randomized, Single‐Center Trial
  3. Combined Use of Botulinum Toxin A and Profhilo for Upper Face Rejuvenation: A Randomized Clinical Trial.