topicHyaluronic Acid Skin Elasticity Randomized Trial
claimHydration increased steadily in the treatment group, exceeding that of the control at all post-treatment time points (P Conclusion Full‑face intradermal NCHA improved skin hydration, elasticity, texture, and fine lines with a favorable safety profile.
evidence level2
citationCheng H (2026)
sourceA Prospective, Multicenter, Randomized, Assessor-Blinded Study Assessing the Efficacy and Safety of Injectable Non-Cross-Linked Hyaluronic Acid for Improving Facial Skin Rejuvenation.
topicHyaluronic Acid Skin Elasticity Randomized Trial
claimObjective To evaluate the efficacy and safety of an injectable non-cross-linked hyaluronic acid (NCHA) solution in improving facial skin appearance.
evidence level2
citationCheng H (2026)
sourceA Prospective, Multicenter, Randomized, Assessor-Blinded Study Assessing the Efficacy and Safety of Injectable Non-Cross-Linked Hyaluronic Acid for Improving Facial Skin Rejuvenation.
topicHyaluronic Acid Skin Elasticity Randomized Trial
claimMethods This prospective, multicenter, randomized, no‑treatment-controlled, assessor-blinded, superiority clinical trial was conducted from December 2023 to July 2024 with 448 adults (224 per arm).
evidence level2
citationCheng H (2026)
sourceA Prospective, Multicenter, Randomized, Assessor-Blinded Study Assessing the Efficacy and Safety of Injectable Non-Cross-Linked Hyaluronic Acid for Improving Facial Skin Rejuvenation.
topicHyaluronic Acid Skin Elasticity Randomized Trial
claimCollagen, along with antioxidants such as curcumin and glutathione, have gained increased utilization/awareness in recent years, providing dermal health benefits especially in women who experience declining or loss of estrogen with aging.
evidence level4
citationArbex Priscila (2026)
sourceCollagen, Curcumin, and Glutathione to Enhance Dermal Health in Aging Women with Declining Estrogen Levels —A Narrative Review
topicHyaluronic Acid Skin Elasticity Randomized Trial
claimThe evidence of oral collagen as a nutraceutical is robust for improving several aspects of dermal health.
evidence level4
citationArbex Priscila (2026)
sourceCollagen, Curcumin, and Glutathione to Enhance Dermal Health in Aging Women with Declining Estrogen Levels —A Narrative Review
topicHyaluronic Acid Skin Elasticity Randomized Trial
claimFor example, the epidermis is without a blood supply and does not have the same circulation and nutrient delivery found in the dermis [–].
evidence level4
citationArbex Priscila (2026)
sourceCollagen, Curcumin, and Glutathione to Enhance Dermal Health in Aging Women with Declining Estrogen Levels —A Narrative Review
topicHyaluronic Acid Skin Elasticity Randomized Trial
claimThe present narrative review is an extension of a larger project that covered polyphenols and phytoestrogens.
evidence level4
citationArbex Priscila (2026)
sourceCollagen, Curcumin, and Glutathione to Enhance Dermal Health in Aging Women with Declining Estrogen Levels —A Narrative Review