Structured evidence table for Hyaluronic Acid Joint Health Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Hyaluronic Acid Joint Health Meta-Analysis | The majority of the literature suggests that IAHA has a positive safety profile despite a few meta-analyses suggesting an increased risk of serious adverse effects. | 2 | Fuggle N (2026) | Expert consensus on hyaluronic acid injections for knee osteoarthritis: a patient-centered approach. |
| Hyaluronic Acid Joint Health Meta-Analysis | Specific to IAHA, patients seek minimally invasive, lower-risk, and non-steroidal options with at least moderate efficacy and advantageous safety profiles. | 2 | Fuggle N (2026) | Expert consensus on hyaluronic acid injections for knee osteoarthritis: a patient-centered approach. |
| Hyaluronic Acid Joint Health Meta-Analysis | Hyaluronic acid (HA) is a linear polysaccharide which occurs naturally as a constituent of synovial fluid. | 2 | Fuggle N (2026) | Expert consensus on hyaluronic acid injections for knee osteoarthritis: a patient-centered approach. |
| Hyaluronic Acid Joint Health Meta-Analysis | The HA concentration in the joint decreases inexorably during the progression of knee osteoarthritis (OA) and so, for nearly five decades, HA has been trialled and used in the treatment of knee OA. | 2 | Fuggle N (2026) | Expert consensus on hyaluronic acid injections for knee osteoarthritis: a patient-centered approach. |
| Hyaluronic Acid Joint Health Meta-Analysis | To ensure a robust synthesis of evidence, we conducted a systematic search of PubMed, Embase, and Web of Science (2020-2025) for high-quality clinical trials, meta-analyses, and guidelines. | 4 | Wang H (2026) | Evolving Strategies for Knee Osteoarthritis: A Narrative Review of Integrated Rehabilitation, Pharmacologic, and Joint-Preserving Interventions. |
| Hyaluronic Acid Joint Health Meta-Analysis | This narrative review evaluates the clinical transition from reactive, surgery-centric models to a proactive, integrated framework to mitigate the profound socioeconomic burden and functional decline associated with the disease. | 4 | Wang H (2026) | Evolving Strategies for Knee Osteoarthritis: A Narrative Review of Integrated Rehabilitation, Pharmacologic, and Joint-Preserving Interventions. |
| Hyaluronic Acid Joint Health Meta-Analysis | We synthesized evidence across non-pharmacological rehabilitation, pharmacotherapy, and advanced joint-preserving surgeries, emphasizing optimal intervention windows and stage-specific mechanobiological requirements. | 4 | Wang H (2026) | Evolving Strategies for Knee Osteoarthritis: A Narrative Review of Integrated Rehabilitation, Pharmacologic, and Joint-Preserving Interventions. |
| Hyaluronic Acid Joint Health Meta-Analysis | Knee osteoarthritis (KOA) is a primary driver of global disability, currently affecting over 365 million adults, with projections suggesting a 74.9% increase by 2050. | 4 | Wang H (2026) | Evolving Strategies for Knee Osteoarthritis: A Narrative Review of Integrated Rehabilitation, Pharmacologic, and Joint-Preserving Interventions. |
Source documents