topicGaba Sleep Meta-Analysis
claimGenetic research further suggests that the heritability of insomnia is higher in women, while neuroimaging studies have revealed functional alterations in brain circuits related to emotional regulation that are strongly associated with insomnia in women [–].
evidence level3
citationKim Hae Ri (2026)
sourceInsomnia and women: exploring vulnerability, impact, and intervention
topicGaba Sleep Meta-Analysis
claimBy integrating evidence across these dimensions, the present work also aims to provide a multidimensional explanation for women’s vulnerability to insomnia and to highlight the need for gender-tailored clinical strategies and future research directions [,].
evidence level3
citationKim Hae Ri (2026)
sourceInsomnia and women: exploring vulnerability, impact, and intervention
topicGaba Sleep Meta-Analysis
claimHowever, studies with indirect relevance were also included when they provided complementary evidence of the underlying mechanisms.
evidence level3
citationKim Hae Ri (2026)
sourceInsomnia and women: exploring vulnerability, impact, and intervention
topicGaba Sleep Meta-Analysis
claim1 3 4 6 4 6 7 Insomnia is one of the most common sleep disorders worldwide, affecting a substantial proportion of the adult population and posing a serious public health concern because of its profound impact on the quality of life [–].
evidence level3
citationKim Hae Ri (2026)
sourceInsomnia and women: exploring vulnerability, impact, and intervention
topicGaba Sleep Meta-Analysis
claimIt is known that high medication complexity scores are associated with poor clinical outcomes (–).
evidence level3
citationWeinhouse Gerald L. (2026)
sourcePharmacotherapy for sleep during critical illness and beyond
topicGaba Sleep Meta-Analysis
claimMedication specifically administered to facilitate sleep has had disappointing results in the ICU, contributes to polypharmacy, and may have unintended consequences such as increasing the risk of delirium and falls.
evidence level3
citationWeinhouse Gerald L. (2026)
sourcePharmacotherapy for sleep during critical illness and beyond
topicGaba Sleep Meta-Analysis
claimSleep disruption is associated with altered CNS electrical activity and organization which may be associated with inefficient clearing of CNS metabolic waste, impaired memory, inattention and poor executive function which are hallmarks of delirium ().
evidence level3
citationWeinhouse Gerald L. (2026)
sourcePharmacotherapy for sleep during critical illness and beyond
topicGaba Sleep Meta-Analysis
claim1 Sleep is a complex process thought to be regulated by both a circadian system closely tied to ambient light and a homeostatic process characterized by increasing pressure to sleep commensurate with increasing duration of wakefulness.
evidence level3
citationWeinhouse Gerald L. (2026)
sourcePharmacotherapy for sleep during critical illness and beyond