Structured evidence table for Folic Acid Pregnancy Guideline, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Folic Acid Pregnancy Guideline | 5 6 7 8 9 However, a significant gap exists globally between folic acid supplementation practices and scientific evidence. | 3 | Li Jiahe (2026) | Best Evidence Summary of Folic Acid Supplementation for Prevention of Neural Tube Defects in Women of Childbearing Age |
| Folic Acid Pregnancy Guideline | A study in China found that only 16.1% of pregnant women took folic acid at the correct time []. | 3 | Li Jiahe (2026) | Best Evidence Summary of Folic Acid Supplementation for Prevention of Neural Tube Defects in Women of Childbearing Age |
| Folic Acid Pregnancy Guideline | A systematic review of global data (2000–2014) found that folate deficiency (serum folate < 10 nmol/L) affected >20% of women of reproductive age in many lower-income countries, while folate insufficiency (red blood cell folate < 906 nmol/L for NTD risk reduction) exceeded 40% in most countries surveyed []. | 3 | Li Jiahe (2026) | Best Evidence Summary of Folic Acid Supplementation for Prevention of Neural Tube Defects in Women of Childbearing Age |
| Folic Acid Pregnancy Guideline | 1 2 3 4 Neural tube defects (NTDs) constitute a major global public health issue, with a prevalence at birth of 18.6 per 10,000 live births worldwide. | 3 | Li Jiahe (2026) | Best Evidence Summary of Folic Acid Supplementation for Prevention of Neural Tube Defects in Women of Childbearing Age |
| Folic Acid Pregnancy Guideline | Uncontrolled maternal seizures increase the risk of maternal morbidity, foetal hypoxia and miscarriage. | 4 | Birbal S (2026) | Evaluation of the management of high-risk obstetric patients living with epilepsy: A retrospective study from KwaZulu-Natal, South Africa. |
| Folic Acid Pregnancy Guideline | Methods A retrospective quantitative study was conducted at a high-risk obstetrics clinic in a public tertiary hospital in KwaZulu-Natal, South Africa, using clinical records from a 5-year period. | 4 | Birbal S (2026) | Evaluation of the management of high-risk obstetric patients living with epilepsy: A retrospective study from KwaZulu-Natal, South Africa. |
| Folic Acid Pregnancy Guideline | Conclusion The study identified gaps in care, including suboptimal AED selection, limited TDM, inconsistent ultrasound use, frequent polytherapy and increased admissions from poor seizure control. | 4 | Birbal S (2026) | Evaluation of the management of high-risk obstetric patients living with epilepsy: A retrospective study from KwaZulu-Natal, South Africa. |
| Folic Acid Pregnancy Guideline | Background Epilepsy affects approximately 60 million individuals worldwide, with women comprising nearly 50% of the cases. | 4 | Birbal S (2026) | Evaluation of the management of high-risk obstetric patients living with epilepsy: A retrospective study from KwaZulu-Natal, South Africa. |
Source documents