metabolic health

Flaxseed Triglycerides Meta-Analysis Evidence Table

Structured evidence table for Flaxseed Triglycerides Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Flaxseed Triglycerides Meta-AnalysisResults The primary outcome, serum hs-CRP, was significantly reduced in the intervention group compared to controls (MD: -0.98 μg/mL, p = 0.034).2Aghamohammadzadeh N (2026)An 8-Week Triple-Blind, Randomized, Placebo-Controlled Trial Evaluating High-Dose Vitamin D3 and Flaxseed Oil for Inflammation and Metabolic Health in Elderly Patients With Type 2 Diabetes: Implications for Clinical Management.
Flaxseed Triglycerides Meta-AnalysisExploratory analyses of secondary outcomes suggested additional potential benefits: total antioxidant capacity improved (MD: +0.60 mmol/L, p p 2 , p p = 0.015), fasting insulin (MD: -0.94 μIU/mL, p = 0.008), homeostatic model assessment of insulin resistance (MD: -1.31, p = 0.001), triglycerides (MD: -15.00 mg/dL, p = 0.020), and total cholesterol (MD: -2.52 mg/dL, p = 0.028).2Aghamohammadzadeh N (2026)An 8-Week Triple-Blind, Randomized, Placebo-Controlled Trial Evaluating High-Dose Vitamin D3 and Flaxseed Oil for Inflammation and Metabolic Health in Elderly Patients With Type 2 Diabetes: Implications for Clinical Management.
Flaxseed Triglycerides Meta-AnalysisPhysical health-related quality of life, including pain scores and physical functioning, also improved significantly ( p Conclusion Cosupplementation with flaxseed oil and high-dose vitamin D 3 significantly reduced systemic inflammation in elderly patients with T2DM.2Aghamohammadzadeh N (2026)An 8-Week Triple-Blind, Randomized, Placebo-Controlled Trial Evaluating High-Dose Vitamin D3 and Flaxseed Oil for Inflammation and Metabolic Health in Elderly Patients With Type 2 Diabetes: Implications for Clinical Management.
Flaxseed Triglycerides Meta-AnalysisAims This study aimed to evaluate the effects of cosupplementation with high-dose vitamin D3 and flaxseed oil on inflammatory markers, oxidative stress, and metabolic health in elderly patients with T2DM.2Aghamohammadzadeh N (2026)An 8-Week Triple-Blind, Randomized, Placebo-Controlled Trial Evaluating High-Dose Vitamin D3 and Flaxseed Oil for Inflammation and Metabolic Health in Elderly Patients With Type 2 Diabetes: Implications for Clinical Management.
Flaxseed Triglycerides Meta-AnalysisHyperglycemia is associated with acute and chronic complications, and in both cases, it affects the cardiovascular system, thereby inherently affecting the entire organism, but mainly the eyes, kidneys, and peripheral nerves [,].2López-Toledo Sabina (2025)Flaxseed Improves Glucose and Lipid Metabolism in Mexican Subjects with Type 2 Diabetes: A Parallel Randomized Clinical Trial
Flaxseed Triglycerides Meta-AnalysisOne of the seeds that presents the most scientific evidence is flaxseed, demonstrating its positive effect on the reduction in biochemical levels of cholesterol, triglycerides, and glucose, due to its high fiber content [,,,,].2López-Toledo Sabina (2025)Flaxseed Improves Glucose and Lipid Metabolism in Mexican Subjects with Type 2 Diabetes: A Parallel Randomized Clinical Trial
Flaxseed Triglycerides Meta-Analysis10 11 12 13 14 15 16 17 18 19 20 21 22 23 The lignans present in flaxseed, due to their antioxidant properties, help reduce the risk of oxidative damage to DNA (deoxyribonucleic acid) [], reduce lipid peroxidation, and prevent oxidative stress [], promoting the production of polyunsaturated fatty acids EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) [,].2López-Toledo Sabina (2025)Flaxseed Improves Glucose and Lipid Metabolism in Mexican Subjects with Type 2 Diabetes: A Parallel Randomized Clinical Trial
Flaxseed Triglycerides Meta-Analysis1 2 Type 2 diabetes is one of the most important health emergencies of the 21st century.2López-Toledo Sabina (2025)Flaxseed Improves Glucose and Lipid Metabolism in Mexican Subjects with Type 2 Diabetes: A Parallel Randomized Clinical Trial
topicFlaxseed Triglycerides Meta-Analysis
claimResults The primary outcome, serum hs-CRP, was significantly reduced in the intervention group compared to controls (MD: -0.98 μg/mL, p = 0.034).
evidence level2
citationAghamohammadzadeh N (2026)
sourceAn 8-Week Triple-Blind, Randomized, Placebo-Controlled Trial Evaluating High-Dose Vitamin D3 and Flaxseed Oil for Inflammation and Metabolic Health in Elderly Patients With Type 2 Diabetes: Implications for Clinical Management.
topicFlaxseed Triglycerides Meta-Analysis
claimExploratory analyses of secondary outcomes suggested additional potential benefits: total antioxidant capacity improved (MD: +0.60 mmol/L, p p 2 , p p = 0.015), fasting insulin (MD: -0.94 μIU/mL, p = 0.008), homeostatic model assessment of insulin resistance (MD: -1.31, p = 0.001), triglycerides (MD: -15.00 mg/dL, p = 0.020), and total cholesterol (MD: -2.52 mg/dL, p = 0.028).
evidence level2
citationAghamohammadzadeh N (2026)
sourceAn 8-Week Triple-Blind, Randomized, Placebo-Controlled Trial Evaluating High-Dose Vitamin D3 and Flaxseed Oil for Inflammation and Metabolic Health in Elderly Patients With Type 2 Diabetes: Implications for Clinical Management.
topicFlaxseed Triglycerides Meta-Analysis
claimPhysical health-related quality of life, including pain scores and physical functioning, also improved significantly ( p Conclusion Cosupplementation with flaxseed oil and high-dose vitamin D 3 significantly reduced systemic inflammation in elderly patients with T2DM.
evidence level2
citationAghamohammadzadeh N (2026)
sourceAn 8-Week Triple-Blind, Randomized, Placebo-Controlled Trial Evaluating High-Dose Vitamin D3 and Flaxseed Oil for Inflammation and Metabolic Health in Elderly Patients With Type 2 Diabetes: Implications for Clinical Management.
topicFlaxseed Triglycerides Meta-Analysis
claimAims This study aimed to evaluate the effects of cosupplementation with high-dose vitamin D3 and flaxseed oil on inflammatory markers, oxidative stress, and metabolic health in elderly patients with T2DM.
evidence level2
citationAghamohammadzadeh N (2026)
sourceAn 8-Week Triple-Blind, Randomized, Placebo-Controlled Trial Evaluating High-Dose Vitamin D3 and Flaxseed Oil for Inflammation and Metabolic Health in Elderly Patients With Type 2 Diabetes: Implications for Clinical Management.
topicFlaxseed Triglycerides Meta-Analysis
claimHyperglycemia is associated with acute and chronic complications, and in both cases, it affects the cardiovascular system, thereby inherently affecting the entire organism, but mainly the eyes, kidneys, and peripheral nerves [,].
evidence level2
citationLópez-Toledo Sabina (2025)
sourceFlaxseed Improves Glucose and Lipid Metabolism in Mexican Subjects with Type 2 Diabetes: A Parallel Randomized Clinical Trial
topicFlaxseed Triglycerides Meta-Analysis
claimOne of the seeds that presents the most scientific evidence is flaxseed, demonstrating its positive effect on the reduction in biochemical levels of cholesterol, triglycerides, and glucose, due to its high fiber content [,,,,].
evidence level2
citationLópez-Toledo Sabina (2025)
sourceFlaxseed Improves Glucose and Lipid Metabolism in Mexican Subjects with Type 2 Diabetes: A Parallel Randomized Clinical Trial
topicFlaxseed Triglycerides Meta-Analysis
claim10 11 12 13 14 15 16 17 18 19 20 21 22 23 The lignans present in flaxseed, due to their antioxidant properties, help reduce the risk of oxidative damage to DNA (deoxyribonucleic acid) [], reduce lipid peroxidation, and prevent oxidative stress [], promoting the production of polyunsaturated fatty acids EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) [,].
evidence level2
citationLópez-Toledo Sabina (2025)
sourceFlaxseed Improves Glucose and Lipid Metabolism in Mexican Subjects with Type 2 Diabetes: A Parallel Randomized Clinical Trial
topicFlaxseed Triglycerides Meta-Analysis
claim1 2 Type 2 diabetes is one of the most important health emergencies of the 21st century.
evidence level2
citationLópez-Toledo Sabina (2025)
sourceFlaxseed Improves Glucose and Lipid Metabolism in Mexican Subjects with Type 2 Diabetes: A Parallel Randomized Clinical Trial

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Source documents

  1. An 8-Week Triple-Blind, Randomized, Placebo-Controlled Trial Evaluating High-Dose Vitamin D3 and Flaxseed Oil for Inflammation and Metabolic Health in Elderly Patients With Type 2 Diabetes: Implications for Clinical Management.
  2. Flaxseed Improves Glucose and Lipid Metabolism in Mexican Subjects with Type 2 Diabetes: A Parallel Randomized Clinical Trial