Structured evidence table for Curcumin Knee Pain Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Curcumin Knee Pain Meta-Analysis | Non-steroidal anti-inflammatory drugs (NSAIDs), as first-line pharmacological agents, provide symptomatic improvement but are associated with gastrointestinal bleeding and cardiovascular risks upon prolonged administration. | 1 | Shi Chuankai (2026) | Efficacy and safety of different curcumin formulations in osteoarthritis: an umbrella review of systematic reviews |
| Curcumin Knee Pain Meta-Analysis | Systematic reviews and meta-analyses of observational studies indicate substantial heterogeneity in NSAID utilization among OA patients, with generally limited evidence quality (). | 1 | Shi Chuankai (2026) | Efficacy and safety of different curcumin formulations in osteoarthritis: an umbrella review of systematic reviews |
| Curcumin Knee Pain Meta-Analysis | Emerging evidence has identified histone lactylation—a lactate-driven epigenetic modification—as a key player in OA progression, suggesting that targeting lactate metabolism or lactylation pathways may offer new therapeutic opportunities (). | 1 | Shi Chuankai (2026) | Efficacy and safety of different curcumin formulations in osteoarthritis: an umbrella review of systematic reviews |
| Curcumin Knee Pain Meta-Analysis | 1 2 4 5 6 7 Osteoarthritis (OA) represents a leading global cause of joint pain and functional disability, substantially impairing patients’ quality of life (). | 1 | Shi Chuankai (2026) | Efficacy and safety of different curcumin formulations in osteoarthritis: an umbrella review of systematic reviews |
| Curcumin Knee Pain Meta-Analysis | Results Compared to the placebo, VAS-101 was associated with greater improvements in the KOOS pain score (primary outcome measure) (β: 5.12; 95% CI: 0.47, 9.77; d = 0.62, p = 0.041), and mean daily pain ratings (F 3, 225 = 4.42; d = 0.55, p = 0.005). | 2 | Lopresti AL (2026) | The effect of a topical curcumin formulation (VAS-101) on knee pain in adults with knee osteoarthritis: a randomised, double-blind, placebo-controlled study. |
| Curcumin Knee Pain Meta-Analysis | In the VAS-101 group, 39.3% of participants reported feeling either much or very much improved, compared with 13.3% in the placebo group ( p = 0.019). | 2 | Lopresti AL (2026) | The effect of a topical curcumin formulation (VAS-101) on knee pain in adults with knee osteoarthritis: a randomised, double-blind, placebo-controlled study. |
| Curcumin Knee Pain Meta-Analysis | Conclusions Conservative dosing of a topically applied curcumin-containing gel (VAS-101), administered every two days for 28 days, is associated with moderate reductions in knee pain in adults with knee osteoarthritis. | 2 | Lopresti AL (2026) | The effect of a topical curcumin formulation (VAS-101) on knee pain in adults with knee osteoarthritis: a randomised, double-blind, placebo-controlled study. |
| Curcumin Knee Pain Meta-Analysis | Background The oral delivery of curcumin has been shown in several studies to have beneficial pain-relieving effects for the treatment of knee osteoarthritis. | 2 | Lopresti AL (2026) | The effect of a topical curcumin formulation (VAS-101) on knee pain in adults with knee osteoarthritis: a randomised, double-blind, placebo-controlled study. |
Source documents