Structured evidence table for Curcumin Knee Osteoarthritis Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Curcumin Knee Osteoarthritis Meta-Analysis | Non-steroidal anti-inflammatory drugs (NSAIDs), as first-line pharmacological agents, provide symptomatic improvement but are associated with gastrointestinal bleeding and cardiovascular risks upon prolonged administration. | 1 | Shi Chuankai (2026) | Efficacy and safety of different curcumin formulations in osteoarthritis: an umbrella review of systematic reviews |
| Curcumin Knee Osteoarthritis Meta-Analysis | Systematic reviews and meta-analyses of observational studies indicate substantial heterogeneity in NSAID utilization among OA patients, with generally limited evidence quality (). | 1 | Shi Chuankai (2026) | Efficacy and safety of different curcumin formulations in osteoarthritis: an umbrella review of systematic reviews |
| Curcumin Knee Osteoarthritis Meta-Analysis | Emerging evidence has identified histone lactylation—a lactate-driven epigenetic modification—as a key player in OA progression, suggesting that targeting lactate metabolism or lactylation pathways may offer new therapeutic opportunities (). | 1 | Shi Chuankai (2026) | Efficacy and safety of different curcumin formulations in osteoarthritis: an umbrella review of systematic reviews |
| Curcumin Knee Osteoarthritis Meta-Analysis | 1 2 4 5 6 7 Osteoarthritis (OA) represents a leading global cause of joint pain and functional disability, substantially impairing patients’ quality of life (). | 1 | Shi Chuankai (2026) | Efficacy and safety of different curcumin formulations in osteoarthritis: an umbrella review of systematic reviews |
| Curcumin Knee Osteoarthritis Meta-Analysis | 1 2 Arthritis constitutes a major global health burden and remains one of the leading causes of chronic pain, disability, and reduced quality of life worldwide. | 3 | Toumi Hechmi (2026) | Curcumin in Arthritis: Molecular Mechanisms, Preclinical Evidence, and Clinical Applications |
| Curcumin Knee Osteoarthritis Meta-Analysis | OA is primarily a degenerative disease associated with aging and mechanical stress, whereas RA is an autoimmune disorder characterized by systemic inflammation and synovial hyperplasia [,]. | 3 | Toumi Hechmi (2026) | Curcumin in Arthritis: Molecular Mechanisms, Preclinical Evidence, and Clinical Applications |
| Curcumin Knee Osteoarthritis Meta-Analysis | Although these therapies can alleviate symptoms and, in some cases, slow disease progression, their long-term use is often associated with significant adverse effects, including gastrointestinal, cardiovascular, renal, and immunological complications []. | 3 | Toumi Hechmi (2026) | Curcumin in Arthritis: Molecular Mechanisms, Preclinical Evidence, and Clinical Applications |
| Curcumin Knee Osteoarthritis Meta-Analysis | The two most prevalent forms, osteoarthritis (OA) and rheumatoid arthritis (RA), differ in etiology but share common pathological features, including joint inflammation, cartilage degradation, and progressive functional impairment. | 3 | Toumi Hechmi (2026) | Curcumin in Arthritis: Molecular Mechanisms, Preclinical Evidence, and Clinical Applications |
Source documents