Structured evidence table for Collagen Skin Elasticity Meta-Analysis, generated from 3 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Collagen Skin Elasticity Meta-Analysis | Introduction Skin aging manifests as wrinkles, reduced elasticity, and roughness due to intrinsic and extrinsic factors. | 1 | Nukaly HY (2026) | Oral and topical peptides for skin aging: systematic review and meta-analysis of randomized controlled trials. |
| Collagen Skin Elasticity Meta-Analysis | Peptides, particularly oral formulations, significantly improved hydration and brightness, with a modest pooled effect on wrinkle reduction (MD = 0.27, p = 0.04). | 1 | Nukaly HY (2026) | Oral and topical peptides for skin aging: systematic review and meta-analysis of randomized controlled trials. |
| Collagen Skin Elasticity Meta-Analysis | Peptide-based therapies enhance collagen synthesis and extracellular matrix integrity. | 1 | Nukaly HY (2026) | Oral and topical peptides for skin aging: systematic review and meta-analysis of randomized controlled trials. |
| Collagen Skin Elasticity Meta-Analysis | Skin hydration/elasticity improved sustainably for 3 months, with only 1.67% adverse events and no serious ones. | 2 | Yang Rongya (2026) | Efficacy and Safety of a Novel Sodium Hyaluronate Composite Solution via Mesotherapy for Facial Rejuvenation: A Multicenter Randomized Controlled Study |
| Collagen Skin Elasticity Meta-Analysis | This large-scale randomized controlled trial complements the existing evidence base for the novel sodium hyaluronate composite, strongly supporting its safty and clinical efficacy in facial rejuvenation through mesotherapy. | 2 | Yang Rongya (2026) | Efficacy and Safety of a Novel Sodium Hyaluronate Composite Solution via Mesotherapy for Facial Rejuvenation: A Multicenter Randomized Controlled Study |
| Collagen Skin Elasticity Meta-Analysis | The GAIS score distribution demonstrated that within the treatment group, 5.57% of subjects were rated as “very much improved,” 41.11% as “much improved,” and 50.87% as “improved.” In contrast, only 6 subjects (3.95%) in the control group showed improvement of any degree, whereas the remainder were rated as “no change” or “worse” (Table). | 2 | Yang Rongya (2026) | Efficacy and Safety of a Novel Sodium Hyaluronate Composite Solution via Mesotherapy for Facial Rejuvenation: A Multicenter Randomized Controlled Study |
| Collagen Skin Elasticity Meta-Analysis | Is this novel sodium hyaluronate composite containing 4 amino acids safe and effective for facial rejuvenation when administered via mesotherapy? | 2 | Yang Rongya (2026) | Efficacy and Safety of a Novel Sodium Hyaluronate Composite Solution via Mesotherapy for Facial Rejuvenation: A Multicenter Randomized Controlled Study |
| Collagen Skin Elasticity Meta-Analysis | The aim of the present study was to carry out an umbrella review with integrated meta-analyses to capture the breadth of health outcomes associated with collagen supplementation intake. | 4 | Ravindran R (2026) | Collagen Supplementation for Skin and Musculoskeletal Health: An Umbrella Review of Meta-Analyses on Elasticity, Hydration, and Structural Outcomes. |
| Collagen Skin Elasticity Meta-Analysis | Meta-regression analyses were conducted to explore potential sources of heterogeneity, and the grading of evidence was carried out using the GRADE. | 4 | Ravindran R (2026) | Collagen Supplementation for Skin and Musculoskeletal Health: An Umbrella Review of Meta-Analyses on Elasticity, Hydration, and Structural Outcomes. |
| Collagen Skin Elasticity Meta-Analysis | In relation to skin, musculoskeletal health, and osteoarthritis conditions, collagen supplementation was consistently associated with favorable outcomes. | 4 | Ravindran R (2026) | Collagen Supplementation for Skin and Musculoskeletal Health: An Umbrella Review of Meta-Analyses on Elasticity, Hydration, and Structural Outcomes. |
| Collagen Skin Elasticity Meta-Analysis | Collagen is a protein with multiple roles within the human body, such as supporting fibroblast formation in the dermis, replacing dead skin cells, protecting organs, giving structure, strength and elasticity to the skin, and a primary role in blood clotting. | 4 | Ravindran R (2026) | Collagen Supplementation for Skin and Musculoskeletal Health: An Umbrella Review of Meta-Analyses on Elasticity, Hydration, and Structural Outcomes. |
Source documents