evidence table

Collagen Osteoarthritis Meta-Analysis Evidence Table

Structured evidence table for Collagen Osteoarthritis Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Collagen Osteoarthritis Meta-AnalysisMenopause-associated estrogen deficiency has been implicated in cartilage degeneration and osteoarthritis (OA) progression.1Tehalia MK (2026)Estrogen Deficiency in Menopause: A Major Contributor to Cartilage Degeneration and Osteoarthritis: A Systematic Review and Meta-Analysis.
Collagen Osteoarthritis Meta-AnalysisThis systematic review and meta-analysis evaluates evidence from human and animal studies.1Tehalia MK (2026)Estrogen Deficiency in Menopause: A Major Contributor to Cartilage Degeneration and Osteoarthritis: A Systematic Review and Meta-Analysis.
Collagen Osteoarthritis Meta-AnalysisEstrogen deficiency is associated with cartilage degeneration, with strong supportive evidence from OVX models.1Tehalia MK (2026)Estrogen Deficiency in Menopause: A Major Contributor to Cartilage Degeneration and Osteoarthritis: A Systematic Review and Meta-Analysis.
Collagen Osteoarthritis Meta-AnalysisDiabetes mellitus, particularly type 2 diabetes, has been associated in some studies with increased osteoarthritis (OA) risk, greater symptom burden, and structural progression; however, epidemiological evidence remains heterogeneous, and the extent to which diabetes independently contributes to OA after accounting for obesity, adiposity, physical inactivity, and other metabolic confounders remains debated.4Li J (2026)Diabetes-Related Metabolic Osteoarthritis: Advanced Glycation-Collagen Axis, Cartilage Stiffening, and Biomaterials-Based Therapeutic Strategies.
Collagen Osteoarthritis Meta-AnalysisIn metabolically susceptible patients, chronic hyperglycemia, insulin resistance, carbonyl stress, and low-grade inflammation may contribute to disruption of the joint microenvironment.4Li J (2026)Diabetes-Related Metabolic Osteoarthritis: Advanced Glycation-Collagen Axis, Cartilage Stiffening, and Biomaterials-Based Therapeutic Strategies.
topicCollagen Osteoarthritis Meta-Analysis
claimMenopause-associated estrogen deficiency has been implicated in cartilage degeneration and osteoarthritis (OA) progression.
evidence level1
citationTehalia MK (2026)
sourceEstrogen Deficiency in Menopause: A Major Contributor to Cartilage Degeneration and Osteoarthritis: A Systematic Review and Meta-Analysis.
topicCollagen Osteoarthritis Meta-Analysis
claimThis systematic review and meta-analysis evaluates evidence from human and animal studies.
evidence level1
citationTehalia MK (2026)
sourceEstrogen Deficiency in Menopause: A Major Contributor to Cartilage Degeneration and Osteoarthritis: A Systematic Review and Meta-Analysis.
topicCollagen Osteoarthritis Meta-Analysis
claimEstrogen deficiency is associated with cartilage degeneration, with strong supportive evidence from OVX models.
evidence level1
citationTehalia MK (2026)
sourceEstrogen Deficiency in Menopause: A Major Contributor to Cartilage Degeneration and Osteoarthritis: A Systematic Review and Meta-Analysis.
topicCollagen Osteoarthritis Meta-Analysis
claimDiabetes mellitus, particularly type 2 diabetes, has been associated in some studies with increased osteoarthritis (OA) risk, greater symptom burden, and structural progression; however, epidemiological evidence remains heterogeneous, and the extent to which diabetes independently contributes to OA after accounting for obesity, adiposity, physical inactivity, and other metabolic confounders remains debated.
evidence level4
citationLi J (2026)
sourceDiabetes-Related Metabolic Osteoarthritis: Advanced Glycation-Collagen Axis, Cartilage Stiffening, and Biomaterials-Based Therapeutic Strategies.
topicCollagen Osteoarthritis Meta-Analysis
claimIn metabolically susceptible patients, chronic hyperglycemia, insulin resistance, carbonyl stress, and low-grade inflammation may contribute to disruption of the joint microenvironment.
evidence level4
citationLi J (2026)
sourceDiabetes-Related Metabolic Osteoarthritis: Advanced Glycation-Collagen Axis, Cartilage Stiffening, and Biomaterials-Based Therapeutic Strategies.

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Source documents

  1. Estrogen Deficiency in Menopause: A Major Contributor to Cartilage Degeneration and Osteoarthritis: A Systematic Review and Meta-Analysis.
  2. Diabetes-Related Metabolic Osteoarthritis: Advanced Glycation-Collagen Axis, Cartilage Stiffening, and Biomaterials-Based Therapeutic Strategies.