evidence table

Collagen Joint Stiffness Meta-Analysis Evidence Table

Structured evidence table for Collagen Joint Stiffness Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Collagen Joint Stiffness Meta-AnalysisHormonal Stabilization of the Bone-Metabolic Environment: Implications for Anterior Cruciate Ligament Integrity and Bone-Graft Integration.4Koren A (2026)Hormonal Stabilization of the Bone-Metabolic Environment: Implications for Anterior Cruciate Ligament Integrity and Bone-Graft Integration.
Collagen Joint Stiffness Meta-Analysis“Diabetes-related OA” refers to OA discussed in the context of diabetes-associated hyperglycemia, insulin resistance, carbonyl stress, AGE accumulation, and inflammatory–matrix alterations.4Li Jiayao (2026)Diabetes-Related Metabolic Osteoarthritis: Advanced Glycation–Collagen Axis, Cartilage Stiffening, and Biomaterials-Based Therapeutic Strategies
Collagen Joint Stiffness Meta-Analysis“Metabolic OA” is a broader phenotype involving systemic metabolic dysfunction, including but not limited to diabetes, obesity, dyslipidemia, adipokine imbalance, and low-grade inflammation.,“Obesity-associated OA” emphasizes the combined contribution of excess mechanical loading and adipose-driven inflammatory/metabolic signaling.4Li Jiayao (2026)Diabetes-Related Metabolic Osteoarthritis: Advanced Glycation–Collagen Axis, Cartilage Stiffening, and Biomaterials-Based Therapeutic Strategies
Collagen Joint Stiffness Meta-Analysis7 8 9–11 Within this conceptual framework, the advanced glycation–collagen (AGE–COL) axis provides a plausible molecular and biomechanical link between diabetes-associated metabolic stress and OA-relevant joint degeneration.4Li Jiayao (2026)Diabetes-Related Metabolic Osteoarthritis: Advanced Glycation–Collagen Axis, Cartilage Stiffening, and Biomaterials-Based Therapeutic Strategies
Collagen Joint Stiffness Meta-Analysis1 2 3 4 Osteoarthritis (OA) is a chronic joint disease with a steadily rising global burden of disability.4Li Jiayao (2026)Diabetes-Related Metabolic Osteoarthritis: Advanced Glycation–Collagen Axis, Cartilage Stiffening, and Biomaterials-Based Therapeutic Strategies
topicCollagen Joint Stiffness Meta-Analysis
claimHormonal Stabilization of the Bone-Metabolic Environment: Implications for Anterior Cruciate Ligament Integrity and Bone-Graft Integration.
evidence level4
citationKoren A (2026)
sourceHormonal Stabilization of the Bone-Metabolic Environment: Implications for Anterior Cruciate Ligament Integrity and Bone-Graft Integration.
topicCollagen Joint Stiffness Meta-Analysis
claim“Diabetes-related OA” refers to OA discussed in the context of diabetes-associated hyperglycemia, insulin resistance, carbonyl stress, AGE accumulation, and inflammatory–matrix alterations.
evidence level4
citationLi Jiayao (2026)
sourceDiabetes-Related Metabolic Osteoarthritis: Advanced Glycation–Collagen Axis, Cartilage Stiffening, and Biomaterials-Based Therapeutic Strategies
topicCollagen Joint Stiffness Meta-Analysis
claim“Metabolic OA” is a broader phenotype involving systemic metabolic dysfunction, including but not limited to diabetes, obesity, dyslipidemia, adipokine imbalance, and low-grade inflammation.,“Obesity-associated OA” emphasizes the combined contribution of excess mechanical loading and adipose-driven inflammatory/metabolic signaling.
evidence level4
citationLi Jiayao (2026)
sourceDiabetes-Related Metabolic Osteoarthritis: Advanced Glycation–Collagen Axis, Cartilage Stiffening, and Biomaterials-Based Therapeutic Strategies
topicCollagen Joint Stiffness Meta-Analysis
claim7 8 9–11 Within this conceptual framework, the advanced glycation–collagen (AGE–COL) axis provides a plausible molecular and biomechanical link between diabetes-associated metabolic stress and OA-relevant joint degeneration.
evidence level4
citationLi Jiayao (2026)
sourceDiabetes-Related Metabolic Osteoarthritis: Advanced Glycation–Collagen Axis, Cartilage Stiffening, and Biomaterials-Based Therapeutic Strategies
topicCollagen Joint Stiffness Meta-Analysis
claim1 2 3 4 Osteoarthritis (OA) is a chronic joint disease with a steadily rising global burden of disability.
evidence level4
citationLi Jiayao (2026)
sourceDiabetes-Related Metabolic Osteoarthritis: Advanced Glycation–Collagen Axis, Cartilage Stiffening, and Biomaterials-Based Therapeutic Strategies

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Source documents

  1. Hormonal Stabilization of the Bone-Metabolic Environment: Implications for Anterior Cruciate Ligament Integrity and Bone-Graft Integration.
  2. Diabetes-Related Metabolic Osteoarthritis: Advanced Glycation–Collagen Axis, Cartilage Stiffening, and Biomaterials-Based Therapeutic Strategies