Structured evidence table for Collagen Joint Pain Meta-Analysis, generated from 4 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Collagen Joint Pain Meta-Analysis | Purpose To assess whether diabetes mellitus (type 1 or type 2) increases the risk of developing adhesive capsulitis (frozen shoulder). | 1 | Hernigou P (2026) | The diabetic shoulder: association between diabetes mellitus and adhesive capsulitis - a systematic review and meta-analysis. |
| Collagen Joint Pain Meta-Analysis | Study quality and bias risk were assessed, and when enough data were available, a random-effects meta-analysis was performed to estimate the general association between diabetes and the development of frozen shoulder. | 1 | Hernigou P (2026) | The diabetic shoulder: association between diabetes mellitus and adhesive capsulitis - a systematic review and meta-analysis. |
| Collagen Joint Pain Meta-Analysis | Several additional risk factors were noted across studies, including poor glycemic control, obesity, hyperlipidaemia, hypertension, thyroid issues, age between 40 and 65, female gender, smoking, and alcohol use. | 1 | Hernigou P (2026) | The diabetic shoulder: association between diabetes mellitus and adhesive capsulitis - a systematic review and meta-analysis. |
| Collagen Joint Pain Meta-Analysis | Methods A systematic review and meta-analysis were conducted in 2026 using multiple electronic databases. | 1 | Hernigou P (2026) | The diabetic shoulder: association between diabetes mellitus and adhesive capsulitis - a systematic review and meta-analysis. |
| Collagen Joint Pain Meta-Analysis | From 1990 to 2020, the prevalence of OA rose by 132.2% while the age-standardized incidence rate increased from 233.0 to 255.0 per 100,000 worldwide []. | 3 | Lee Woojin (2026) | Current State of Orthobiologics in Treatment of Knee Osteoarthritis—Future Directions |
| Collagen Joint Pain Meta-Analysis | Current standard treatments for knee OA, including exercise, weight loss, NSAIDs, topical agents, corticosteroid or hyaluronic acid injections, and radiofrequency ablation, have not been effective in decreasing the incidence of knee OA, ultimately resulting in an increased need for surgical intervention such as total knee arthroplasty [,,,,,,,,,,,,,,,]. | 3 | Lee Woojin (2026) | Current State of Orthobiologics in Treatment of Knee Osteoarthritis—Future Directions |
| Collagen Joint Pain Meta-Analysis | Therefore, if orthobiologics can sufficiently prove their regenerative effect on degenerative conditions such as knee OA, it may result in a regression of knee OA prevalence, resulting in a decreasing disease burden worldwide, providing better quality of life in the aging population, and significantly lowering medical costs in managing this condition. | 3 | Lee Woojin (2026) | Current State of Orthobiologics in Treatment of Knee Osteoarthritis—Future Directions |
| Collagen Joint Pain Meta-Analysis | 1 2 3 4 1 1 2 3 4 5 6 7 8 9 10 11 12 13 3 4 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 Orthobiologics have been gaining popularity in recent years as both incidence and prevalence of joint osteoarthritis (OA) continue to increase globally [,,,]. | 3 | Lee Woojin (2026) | Current State of Orthobiologics in Treatment of Knee Osteoarthritis—Future Directions |
| Collagen Joint Pain Meta-Analysis | “Diabetes-related OA” refers to OA discussed in the context of diabetes-associated hyperglycemia, insulin resistance, carbonyl stress, AGE accumulation, and inflammatory–matrix alterations. | 4 | Li Jiayao (2026) | Diabetes-Related Metabolic Osteoarthritis: Advanced Glycation–Collagen Axis, Cartilage Stiffening, and Biomaterials-Based Therapeutic Strategies |
| Collagen Joint Pain Meta-Analysis | “Metabolic OA” is a broader phenotype involving systemic metabolic dysfunction, including but not limited to diabetes, obesity, dyslipidemia, adipokine imbalance, and low-grade inflammation.,“Obesity-associated OA” emphasizes the combined contribution of excess mechanical loading and adipose-driven inflammatory/metabolic signaling. | 4 | Li Jiayao (2026) | Diabetes-Related Metabolic Osteoarthritis: Advanced Glycation–Collagen Axis, Cartilage Stiffening, and Biomaterials-Based Therapeutic Strategies |
| Collagen Joint Pain Meta-Analysis | 7 8 9–11 Within this conceptual framework, the advanced glycation–collagen (AGE–COL) axis provides a plausible molecular and biomechanical link between diabetes-associated metabolic stress and OA-relevant joint degeneration. | 4 | Li Jiayao (2026) | Diabetes-Related Metabolic Osteoarthritis: Advanced Glycation–Collagen Axis, Cartilage Stiffening, and Biomaterials-Based Therapeutic Strategies |
| Collagen Joint Pain Meta-Analysis | 1 2 3 4 Osteoarthritis (OA) is a chronic joint disease with a steadily rising global burden of disability. | 4 | Li Jiayao (2026) | Diabetes-Related Metabolic Osteoarthritis: Advanced Glycation–Collagen Axis, Cartilage Stiffening, and Biomaterials-Based Therapeutic Strategies |
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