Structured evidence table for Collagen Joint Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Collagen Joint Meta-Analysis | Background In recent years, the number of animal studies investigating mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) therapy for osteochondral defects has steadily increased. | 1 | Wen Y (2026) | Mesenchymal stem cell-derived extracellular vesicles for osteochondral defect regeneration: a systematic review and meta-analysis of preclinical studies. |
| Collagen Joint Meta-Analysis | MSC-EVs intervention improved International Cartilage Repair Society (ICRS) and Modified O'Driscoll Scale (MODS) scores at both 3 and 6 months, and significantly increased BV/TV, Tb.Th, as well as histological scores of cartilage and subchondral bone. | 1 | Wen Y (2026) | Mesenchymal stem cell-derived extracellular vesicles for osteochondral defect regeneration: a systematic review and meta-analysis of preclinical studies. |
| Collagen Joint Meta-Analysis | Conclusions MSC-EVs improved osteochondral repair scores, bone structural parameters, and histological outcomes in preclinical models, indicating their potential for promoting osteochondral regeneration. | 1 | Wen Y (2026) | Mesenchymal stem cell-derived extracellular vesicles for osteochondral defect regeneration: a systematic review and meta-analysis of preclinical studies. |
| Collagen Joint Meta-Analysis | This meta-analysis aimed to evaluate the efficacy of MSC-EVs in animal models of osteochondral defect through a meta-analysis. | 1 | Wen Y (2026) | Mesenchymal stem cell-derived extracellular vesicles for osteochondral defect regeneration: a systematic review and meta-analysis of preclinical studies. |
| Collagen Joint Meta-Analysis | Importantly, these biological changes manifest most meaningfully through declines in functional capacity, including reduced muscle strength, impaired metabolic regulation, diminished cognitive performance, and increased disease risk. | 4 | Kurtz Jennifer A. (2026) | Targeted Supplementation and Nutritional Strategies for Healthy Aging: A Review of Physiological and Molecular Benefits |
| Collagen Joint Meta-Analysis | This article aims to synthesize evidence from human studies evaluating dietary supplements that directly or indirectly modulate the recognized hallmarks of aging, such as mitochondrial dysfunction, oxidative stress, inflammation, and proteostasis. | 4 | Kurtz Jennifer A. (2026) | Targeted Supplementation and Nutritional Strategies for Healthy Aging: A Review of Physiological and Molecular Benefits |
| Collagen Joint Meta-Analysis | Rather than providing an exhaustive account of all supplements ever studied, this review focuses on representative compounds with the strongest or most emerging human evidence. | 4 | Kurtz Jennifer A. (2026) | Targeted Supplementation and Nutritional Strategies for Healthy Aging: A Review of Physiological and Molecular Benefits |
| Collagen Joint Meta-Analysis | Aging is a complex, multifaceted process marked by a gradual decline in physiological. | 4 | Kurtz Jennifer A. (2026) | Targeted Supplementation and Nutritional Strategies for Healthy Aging: A Review of Physiological and Molecular Benefits |
Source documents