Structured evidence table for Coenzyme Q10 Migraine Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Coenzyme Q10 Migraine Meta-Analysis | 1 2 3 4 5 Migraine is a chronic, disabling neurovascular disorder characterized by recurrent episodes of moderate-to-severe headache, typically unilateral and pulsating in quality, and frequently associated with nausea, vomiting, photophobia, and phonophobia. | 3 | Santangelo Domenico (2026) | Dietary Modulation of Migraine: Metabolic, Neuroinflammatory and Microbiota-Mediated Mechanisms |
| Coenzyme Q10 Migraine Meta-Analysis | These processes result in peripheral and central sensitization of nociceptive pathways, thereby amplifying pain perception and contributing to migraine chronicization []. | 3 | Santangelo Domenico (2026) | Dietary Modulation of Migraine: Metabolic, Neuroinflammatory and Microbiota-Mediated Mechanisms |
| Coenzyme Q10 Migraine Meta-Analysis | 6 7 6 8 9 10 11 A growing body of evidence indicates that patients with migraine show impaired energy metabolism and reduced metabolic flexibility []. | 3 | Santangelo Domenico (2026) | Dietary Modulation of Migraine: Metabolic, Neuroinflammatory and Microbiota-Mediated Mechanisms |
| Coenzyme Q10 Migraine Meta-Analysis | In approximately one-third of patients, migraine attacks are preceded or accompanied by transient focal neurological symptoms, known as aura, which most frequently manifests as visual disturbances but may also involve sensory, language, or motor symptoms []. | 3 | Santangelo Domenico (2026) | Dietary Modulation of Migraine: Metabolic, Neuroinflammatory and Microbiota-Mediated Mechanisms |
| Coenzyme Q10 Migraine Meta-Analysis | A growing body of evidence points to a significant link between migraine and disruptions in brain energy metabolism (). | 3 | Sun Wen-xiu (2025) | Energy metabolism disorders in migraine: triggers, pathways, and therapeutic repurposing |
| Coenzyme Q10 Migraine Meta-Analysis | As a result, prophylactic treatments for migraine that target brain energy metabolism, including riboflavin, coenzyme Q10, alpha-lipoic acid (ALA), and ketogenic diet (KD), have gained increasing attention (). | 3 | Sun Wen-xiu (2025) | Energy metabolism disorders in migraine: triggers, pathways, and therapeutic repurposing |
| Coenzyme Q10 Migraine Meta-Analysis | () 25,492,827 100 mg/day, 10 days n Migraine rat model ( = 30) Reduced oxidative damage and protected against glyceryl trinitrate-induced headaches 82 Das and Qubty () 33,189,027 100 or 200 mg/day, 3 months n Children and adolescents ( = 42) ↓ Migraine frequency, intensity and duration Coenzyme Q10 93 Rozen et al. | 3 | Sun Wen-xiu (2025) | Energy metabolism disorders in migraine: triggers, pathways, and therapeutic repurposing |
| Coenzyme Q10 Migraine Meta-Analysis | 1 2 3 4 5 6 7 8 Table 1 Among 369 diseases analyzed across 204 countries, headache disorders ranked 14th in disability-adjusted life years (DALYs) for the general population and were positioned as the second leading cause of DALYs in females aged 15–49 years (). | 3 | Sun Wen-xiu (2025) | Energy metabolism disorders in migraine: triggers, pathways, and therapeutic repurposing |
Source documents