Structured evidence table for Citicoline Supplementation Cognitive Function Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Citicoline Supplementation Cognitive Function Randomized Trial | 41 17 42 17 + 2+ 3 Chronic treatment of aged rats with GPC restored the number of muscarinic Mreceptors to levels found in the striatum and hippocampus from young animals (). | 3 | Kansakar Urna (2023) | Choline supplements: An update |
| Citicoline Supplementation Cognitive Function Randomized Trial | Repeated injections of GPC significantly increased basal formation of [H]inositol monophosphate in hippocampal, cortical, and striatal slices of male rats (). | 3 | Kansakar Urna (2023) | Choline supplements: An update |
| Citicoline Supplementation Cognitive Function Randomized Trial | 43 44 in vitro In a model of acute cerebral ischemia in rats, GPC increased the tolerance of neurons to ischemic damage and slowed the execution of the cell death program (). | 3 | Kansakar Urna (2023) | Choline supplements: An update |
| Citicoline Supplementation Cognitive Function Randomized Trial | 1 5 6 7 Choline is an important nutrient essential for proper functioning of liver, muscle, and brain (–). | 3 | Kansakar Urna (2023) | Choline supplements: An update |
| Citicoline Supplementation Cognitive Function Randomized Trial | These claims were accepted because they were substantiated by observations that choline deficiency is associated with signs of liver damage (elevated serum alanine aminotransferase activity) and the development of fatty liver (hepatosteatosis) in humans fed choline-free total parenteral nutrition solutions, whose effects can be reversed by the administration of dietary choline [,]. | 4 | Synoradzki Kamil (2019) | Citicoline: A Superior Form of Choline? |
| Citicoline Supplementation Cognitive Function Randomized Trial | There is a large and growing amount of literature on the atherogenicity of TMAO resulting in increased incidence of myocardial infarction, stroke, or death []. | 4 | Synoradzki Kamil (2019) | Citicoline: A Superior Form of Choline? |
| Citicoline Supplementation Cognitive Function Randomized Trial | A meta-analysis published recently led to the conclusion that higher plasma TMAO correlates with a 23% increase in risk for cardiovascular events and a 55% increase in all-cause mortality []. | 4 | Synoradzki Kamil (2019) | Citicoline: A Superior Form of Choline? |
| Citicoline Supplementation Cognitive Function Randomized Trial | 1 2 3 Citicoline is the international nonproprietary name (INN) for cytidine-diphosphocholine (CDP-Cho). | 4 | Synoradzki Kamil (2019) | Citicoline: A Superior Form of Choline? |
Source documents