Is Sage Supplementation Cognitive Function Randomized Trial safe?

Updated October 2026

Quick Answer

Sage Supplementation Cognitive Function Randomized Trial has evidence relevant to safety, limits, and clinician-discussion contexts, but conclusions should stay close to the cited sources. One representative finding is: Conclusion: The combination of Salvia improved the cognitive functions (perceived exertion, working memory, and reaction time).

Key Takeaways

  • 01Conclusion: The combination of Salvia improved the cognitive functions (perceived exertion, working memory, and reaction time). [Babault N (2021)]
  • 02Background: Salvia (sage) supplementation has been shown to improve the cognition function in healthy individuals or patients (e.g., attention, memory). [Babault N (2021)]
  • 03To date, no study has explored its relevancy in the context of sporting performance. [Babault N (2021)]
  • 04A preclinical in vivo study in rodents, however, has demonstrated improved cognitive outcomes following 2-week consumption of Cognivia TM , a proprietary extract of both Salvia officinalis polyphenols and Salvia lavandulaefolia terpenoids, suggesting that a combination of phytochemicals from sage might be more efficacious over a longer period of time. [Wightman EL (2021)]
The current Migaku evidence database contains 2 reusable source documents for Sage Supplementation Cognitive Function Randomized Trial. This answer focuses on safety, limits, and clinician-discussion contexts. - Conclusion: The combination of Salvia improved the cognitive functions (perceived exertion, working memory, and reaction time). [Babault N (2021); evidence level 2] - Background: Salvia (sage) supplementation has been shown to improve the cognition function in healthy individuals or patients (e.g., attention, memory). [Babault N (2021); evidence level 2] - To date, no study has explored its relevancy in the context of sporting performance. [Babault N (2021); evidence level 2] - A preclinical in vivo study in rodents, however, has demonstrated improved cognitive outcomes following 2-week consumption of Cognivia TM , a proprietary extract of both Salvia officinalis polyphenols and Salvia lavandulaefolia terpenoids, suggesting that a combination of phytochemicals from sage might be more efficacious over a longer period of time. [Wightman EL (2021); evidence level 2] - The sage ( Salvia ) plant contains a host of terpenes and phenolics which interact with mechanisms pertinent to brain function and improve aspects of cognitive performance. [Wightman EL (2021); evidence level 2] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.

Sources

  1. Acute Effects of <i>Salvia</i> Supplementation on Cognitive Function in Athletes During a Fatiguing Cycling Exercise: A Randomized Cross-Over, Placebo-Controlled, and Double-Blind Study.
  2. The Acute and Chronic Cognitive Effects of a Sage Extract: A Randomized, Placebo Controlled Study in Healthy Humans.