evidence table

Cacao Flavanol Sleep Quality Meta-Analysis Evidence Table

Structured evidence table for Cacao Flavanol Sleep Quality Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Cacao Flavanol Sleep Quality Meta-AnalysisMetS is a multifactorial condition, with its primary indicators including obesity, hypertension, dyslipidemia, insulin resistance, and hyperglycemia; i.e., a patient who possesses at least 3 of the following parameters is designated with MetS: glucose intolerance, increased levels of triglycerides, augmented waist circumference, low levels of high-density lipoprotein cholesterol (HDL-c), and hypertension [,,].3Tomaru Júlia Mayumi (2026)Beyond Taste: The Impact of Chocolate on Cardiovascular and Steatotic Liver Disease Risk Factors
Cacao Flavanol Sleep Quality Meta-AnalysisIt is possible to develop a close relationship with MetS, metabolic dysfunction-associated steatotic liver disease (MASLD), and CVD [,].3Tomaru Júlia Mayumi (2026)Beyond Taste: The Impact of Chocolate on Cardiovascular and Steatotic Liver Disease Risk Factors
Cacao Flavanol Sleep Quality Meta-AnalysisMASLD is strongly associated with various conditions, including MetS, and is characterized by the persistence of a chronic inflammatory state detrimental to the organism [,].3Tomaru Júlia Mayumi (2026)Beyond Taste: The Impact of Chocolate on Cardiovascular and Steatotic Liver Disease Risk Factors
Cacao Flavanol Sleep Quality Meta-Analysis1 2 3 4 5 6 7 8 9 10 11 12 13 14 Metabolic disorders are increasing sharply due to severe modifications in lifestyle [,,,].3Tomaru Júlia Mayumi (2026)Beyond Taste: The Impact of Chocolate on Cardiovascular and Steatotic Liver Disease Risk Factors
Cacao Flavanol Sleep Quality Meta-AnalysisFollowing a single gavage dose of FLs to mice, spontaneous motor activity in the open field and improved short-term memory in the novel object test were enhanced.4Fujii Y (2025)Astringent flavanol fires the locus-noradrenergic system, regulating neurobehavior and autonomic nerves.
Cacao Flavanol Sleep Quality Meta-AnalysisConcurrently, activation of stress response systems, such as the sympathetic-adrenal-medullary axis (increased urinary catecholamines) and the hypothalamic-pituitary-adrenal axis (increased corticotropin-releasing hormone mRNA in paraventricular nucleus) was also observed.4Fujii Y (2025)Astringent flavanol fires the locus-noradrenergic system, regulating neurobehavior and autonomic nerves.
Cacao Flavanol Sleep Quality Meta-AnalysisFurthermore, increased NA in the nucleus accumbens was observed as a response to visceral sensations induced by oral FLs administration.4Fujii Y (2025)Astringent flavanol fires the locus-noradrenergic system, regulating neurobehavior and autonomic nerves.
Cacao Flavanol Sleep Quality Meta-AnalysisAstringency is a characteristic exhibited by only a limited number of polyphenolic compounds which show high electrochemical activity and are susceptible to oxidation at neutral pH conditions like the oral cavity and small intestine.4Fujii Y (2025)Astringent flavanol fires the locus-noradrenergic system, regulating neurobehavior and autonomic nerves.
topicCacao Flavanol Sleep Quality Meta-Analysis
claimMetS is a multifactorial condition, with its primary indicators including obesity, hypertension, dyslipidemia, insulin resistance, and hyperglycemia; i.e., a patient who possesses at least 3 of the following parameters is designated with MetS: glucose intolerance, increased levels of triglycerides, augmented waist circumference, low levels of high-density lipoprotein cholesterol (HDL-c), and hypertension [,,].
evidence level3
citationTomaru Júlia Mayumi (2026)
sourceBeyond Taste: The Impact of Chocolate on Cardiovascular and Steatotic Liver Disease Risk Factors
topicCacao Flavanol Sleep Quality Meta-Analysis
claimIt is possible to develop a close relationship with MetS, metabolic dysfunction-associated steatotic liver disease (MASLD), and CVD [,].
evidence level3
citationTomaru Júlia Mayumi (2026)
sourceBeyond Taste: The Impact of Chocolate on Cardiovascular and Steatotic Liver Disease Risk Factors
topicCacao Flavanol Sleep Quality Meta-Analysis
claimMASLD is strongly associated with various conditions, including MetS, and is characterized by the persistence of a chronic inflammatory state detrimental to the organism [,].
evidence level3
citationTomaru Júlia Mayumi (2026)
sourceBeyond Taste: The Impact of Chocolate on Cardiovascular and Steatotic Liver Disease Risk Factors
topicCacao Flavanol Sleep Quality Meta-Analysis
claim1 2 3 4 5 6 7 8 9 10 11 12 13 14 Metabolic disorders are increasing sharply due to severe modifications in lifestyle [,,,].
evidence level3
citationTomaru Júlia Mayumi (2026)
sourceBeyond Taste: The Impact of Chocolate on Cardiovascular and Steatotic Liver Disease Risk Factors
topicCacao Flavanol Sleep Quality Meta-Analysis
claimFollowing a single gavage dose of FLs to mice, spontaneous motor activity in the open field and improved short-term memory in the novel object test were enhanced.
evidence level4
citationFujii Y (2025)
sourceAstringent flavanol fires the locus-noradrenergic system, regulating neurobehavior and autonomic nerves.
topicCacao Flavanol Sleep Quality Meta-Analysis
claimConcurrently, activation of stress response systems, such as the sympathetic-adrenal-medullary axis (increased urinary catecholamines) and the hypothalamic-pituitary-adrenal axis (increased corticotropin-releasing hormone mRNA in paraventricular nucleus) was also observed.
evidence level4
citationFujii Y (2025)
sourceAstringent flavanol fires the locus-noradrenergic system, regulating neurobehavior and autonomic nerves.
topicCacao Flavanol Sleep Quality Meta-Analysis
claimFurthermore, increased NA in the nucleus accumbens was observed as a response to visceral sensations induced by oral FLs administration.
evidence level4
citationFujii Y (2025)
sourceAstringent flavanol fires the locus-noradrenergic system, regulating neurobehavior and autonomic nerves.
topicCacao Flavanol Sleep Quality Meta-Analysis
claimAstringency is a characteristic exhibited by only a limited number of polyphenolic compounds which show high electrochemical activity and are susceptible to oxidation at neutral pH conditions like the oral cavity and small intestine.
evidence level4
citationFujii Y (2025)
sourceAstringent flavanol fires the locus-noradrenergic system, regulating neurobehavior and autonomic nerves.

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Source documents

  1. Beyond Taste: The Impact of Chocolate on Cardiovascular and Steatotic Liver Disease Risk Factors
  2. Astringent flavanol fires the locus-noradrenergic system, regulating neurobehavior and autonomic nerves.