topicBoron Sleep Meta-Analysis
claimObjective To test the feasibility of a smartphone app, BebeApp, that provides evidence-based early childhood development (ECD) guidance in rural Guatemala and pilot procedures for an adequately powered randomised controlled trial.
evidence level2
citationTschida S (2026)
sourceSmartphone-based support for early childhood development in a rural low-resource setting: an individually randomised pilot feasibility trial from Guatemala.
topicBoron Sleep Meta-Analysis
claimInterventions BebeApp provides age-dependent, evidence-based caregiver guidance for breastfeeding and complementary feeding, sleep and developmental support.
evidence level2
citationTschida S (2026)
sourceSmartphone-based support for early childhood development in a rural low-resource setting: an individually randomised pilot feasibility trial from Guatemala.
topicBoron Sleep Meta-Analysis
claimUsability was found to be acceptable but no difference was found between pre-measurements and post-measurements.
evidence level2
citationTschida S (2026)
sourceSmartphone-based support for early childhood development in a rural low-resource setting: an individually randomised pilot feasibility trial from Guatemala.
topicBoron Sleep Meta-Analysis
claimDesign We conducted an individually randomised pilot feasibility trial to compare BebeApp to printed ECD guidance.
evidence level2
citationTschida S (2026)
sourceSmartphone-based support for early childhood development in a rural low-resource setting: an individually randomised pilot feasibility trial from Guatemala.
topicBoron Sleep Meta-Analysis
claimWhile a gradual decline in testosterone with advancing age is well recognized—most notably in men aged 70–80 years, and progressively in women during the premenopausal period with a stabilization or a modest increase after menopause [,]—cumulative evidence has documented an additional, age-independent decline in men.
evidence level3
citationFraile-Martínez Óscar (2026)
sourceUnderstanding the Secular Decline in Testosterone: Mechanisms, Consequences, and Clinical Perspectives
topicBoron Sleep Meta-Analysis
claimFrom a medical perspective, low testosterone levels (clinically diagnosed as hypogonadism) are strongly associated with various chronic maladies including metabolic syndrome, cardiovascular disease and overall mortality [,,,,].
evidence level3
citationFraile-Martínez Óscar (2026)
sourceUnderstanding the Secular Decline in Testosterone: Mechanisms, Consequences, and Clinical Perspectives
topicBoron Sleep Meta-Analysis
claimPsychologically and socially, low testosterone levels are linked to increased rates of depression, anxiety, reduced motivation, lower quality of life, and impaired social behaviors such as competitiveness and engagement [,,,,].
evidence level3
citationFraile-Martínez Óscar (2026)
sourceUnderstanding the Secular Decline in Testosterone: Mechanisms, Consequences, and Clinical Perspectives
topicBoron Sleep Meta-Analysis
claim1 2 3 4 5 Testosterone is one of the most extensively studied hormones in endocrinology, yet its clinical significance continues to evolve as our understanding of its complex physiological roles deepens.
evidence level3
citationFraile-Martínez Óscar (2026)
sourceUnderstanding the Secular Decline in Testosterone: Mechanisms, Consequences, and Clinical Perspectives