Blueberry Sleep Meta-Analysis Evidence Table

Structured evidence table for Blueberry Sleep Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Blueberry Sleep Meta-AnalysisTart cherry juice, rich in melatonin, has been linked to improved sleep duration and quality [,,].2Shoji Kentaro (2026)Hyperoside-Rich Blueberry Leaf Tea Improves Sleep Continuity in Adults with Poor Sleep: A Two-Week Randomized Double-Blind Controlled Trial
Blueberry Sleep Meta-Analysis15 Given this background, our previous interventional trial served as a pilot study to explore the sleep-improving effects of hyperoside, a flavonoid abundantly found in blueberry leaves [].2Shoji Kentaro (2026)Hyperoside-Rich Blueberry Leaf Tea Improves Sleep Continuity in Adults with Poor Sleep: A Two-Week Randomized Double-Blind Controlled Trial
Blueberry Sleep Meta-AnalysisFollowing fermentation, the leaves were brought to room temperature (25 °C) and dried at 70 °C using a hot-air dryer until the moisture content was reduced to below 5%.2Shoji Kentaro (2026)Hyperoside-Rich Blueberry Leaf Tea Improves Sleep Continuity in Adults with Poor Sleep: A Two-Week Randomized Double-Blind Controlled Trial
Blueberry Sleep Meta-Analysis1 2 3 4 5 6 Sleep is essential for maintaining overall health and well-being; however, sleep problems remain a major public health concern.2Shoji Kentaro (2026)Hyperoside-Rich Blueberry Leaf Tea Improves Sleep Continuity in Adults with Poor Sleep: A Two-Week Randomized Double-Blind Controlled Trial
Blueberry Sleep Meta-AnalysisPolyphenols strengthen the intestinal barrier and reduce endotoxemia; cocoa bean shell extracts protected against oxysterol‐induced intestinal damage and improved gut microbiota composition in preclinical models (Alia et al. ).3Akif Adnan (2026)Dietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities
Blueberry Sleep Meta-AnalysisWhile many epidemiological studies correlate polyphenol‐rich diets (e.g., Mediterranean diet) with reduced NCCD risk, causality is uncertain due to confounding and measurement error.3Akif Adnan (2026)Dietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities
Blueberry Sleep Meta-AnalysisControlled trials provide more robust evidence but vary widely in doses, formulations, populations and endpoints.3Akif Adnan (2026)Dietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities
Blueberry Sleep Meta-AnalysisAMP BBB CNS COMT COSMOS CRP (hs‐CRP) CSF EGCG ENB‐2 (ENB) ENS EVOO FMD GAD‐7 (GAD) GM‐CSF (GM) HDL HOMA‐IR (HOMA) IBS IL IR LDL LPS MCI MMSE NADPH NCCD (NCCDs) PHGG PHQ‐9 (PHQ) PSQI PWV RBANS RCT SCFA SD TNF (TNF‐α) 2024 Non‐communicable chronic diseases account for the majority of morbidity and mortality worldwide.3Akif Adnan (2026)Dietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities
topicBlueberry Sleep Meta-Analysis
claimTart cherry juice, rich in melatonin, has been linked to improved sleep duration and quality [,,].
evidence level2
citationShoji Kentaro (2026)
sourceHyperoside-Rich Blueberry Leaf Tea Improves Sleep Continuity in Adults with Poor Sleep: A Two-Week Randomized Double-Blind Controlled Trial
topicBlueberry Sleep Meta-Analysis
claim15 Given this background, our previous interventional trial served as a pilot study to explore the sleep-improving effects of hyperoside, a flavonoid abundantly found in blueberry leaves [].
evidence level2
citationShoji Kentaro (2026)
sourceHyperoside-Rich Blueberry Leaf Tea Improves Sleep Continuity in Adults with Poor Sleep: A Two-Week Randomized Double-Blind Controlled Trial
topicBlueberry Sleep Meta-Analysis
claimFollowing fermentation, the leaves were brought to room temperature (25 °C) and dried at 70 °C using a hot-air dryer until the moisture content was reduced to below 5%.
evidence level2
citationShoji Kentaro (2026)
sourceHyperoside-Rich Blueberry Leaf Tea Improves Sleep Continuity in Adults with Poor Sleep: A Two-Week Randomized Double-Blind Controlled Trial
topicBlueberry Sleep Meta-Analysis
claim1 2 3 4 5 6 Sleep is essential for maintaining overall health and well-being; however, sleep problems remain a major public health concern.
evidence level2
citationShoji Kentaro (2026)
sourceHyperoside-Rich Blueberry Leaf Tea Improves Sleep Continuity in Adults with Poor Sleep: A Two-Week Randomized Double-Blind Controlled Trial
topicBlueberry Sleep Meta-Analysis
claimPolyphenols strengthen the intestinal barrier and reduce endotoxemia; cocoa bean shell extracts protected against oxysterol‐induced intestinal damage and improved gut microbiota composition in preclinical models (Alia et al. ).
evidence level3
citationAkif Adnan (2026)
sourceDietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities
topicBlueberry Sleep Meta-Analysis
claimWhile many epidemiological studies correlate polyphenol‐rich diets (e.g., Mediterranean diet) with reduced NCCD risk, causality is uncertain due to confounding and measurement error.
evidence level3
citationAkif Adnan (2026)
sourceDietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities
topicBlueberry Sleep Meta-Analysis
claimControlled trials provide more robust evidence but vary widely in doses, formulations, populations and endpoints.
evidence level3
citationAkif Adnan (2026)
sourceDietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities
topicBlueberry Sleep Meta-Analysis
claimAMP BBB CNS COMT COSMOS CRP (hs‐CRP) CSF EGCG ENB‐2 (ENB) ENS EVOO FMD GAD‐7 (GAD) GM‐CSF (GM) HDL HOMA‐IR (HOMA) IBS IL IR LDL LPS MCI MMSE NADPH NCCD (NCCDs) PHGG PHQ‐9 (PHQ) PSQI PWV RBANS RCT SCFA SD TNF (TNF‐α) 2024 Non‐communicable chronic diseases account for the majority of morbidity and mortality worldwide.
evidence level3
citationAkif Adnan (2026)
sourceDietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities

Source documents

  1. Hyperoside-Rich Blueberry Leaf Tea Improves Sleep Continuity in Adults with Poor Sleep: A Two-Week Randomized Double-Blind Controlled Trial
  2. Dietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities