evidence table
Black Seed Sleep Meta-Analysis Evidence Table
Structured evidence table for Black Seed Sleep Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Black Seed Sleep Meta-Analysis | 2022 Beyond single molecular biomarkers, the integration of digital biomarkers with molecular detection has also emerged as a promising direction, with digital risk scores showing high sensitivity in identifying individuals with α‐synuclein aggregation or dopaminergic deficit (Schalkamp et al. ). | 3 | Kong Weijie (2026) | Seed Amplification Assays for Parkinson's Disease: A Review of α‐Synuclein Assays in Body Fluids and Tissues |
| Black Seed Sleep Meta-Analysis | In prodromal screening, SAA positivity in the iRBD population suggests a high risk of progression to typical synucleinopathy (Rossi ; Brown et al. ), and emerging evidence has also linked subclinical Lewy body pathology to subtle cognitive changes in clinically unimpaired individuals (Palmqvist et al. ), providing a critical time window for early intervention and risk stratification. | 3 | Kong Weijie (2026) | Seed Amplification Assays for Parkinson's Disease: A Review of α‐Synuclein Assays in Body Fluids and Tissues |
| Black Seed Sleep Meta-Analysis | Despite the promising prospects, SAA still faces challenges, including insufficient standardization of detection procedures, lack of systematic evaluation of the diagnostic performance of varying biological samples, and differences in the result interpretation between laboratories. | 3 | Kong Weijie (2026) | Seed Amplification Assays for Parkinson's Disease: A Review of α‐Synuclein Assays in Body Fluids and Tissues |
| Black Seed Sleep Meta-Analysis | Its typical pathological features are the progressive loss of dopaminergic neurons in the midbrain substantia nigra and the formation of intracellular Lewy bodies (Carrazana et al. ; Iranzo et al. ). | 3 | Kong Weijie (2026) | Seed Amplification Assays for Parkinson's Disease: A Review of α‐Synuclein Assays in Body Fluids and Tissues |
| Black Seed Sleep Meta-Analysis | Extensive neurobiological and clinical research has demonstrated strong associations between sleep disruption and heightened systemic inflammation, which is linked to increased vulnerability to chronic disease [,,]. | 4 | Kovitkanit Piphat (2026) | Mechanistic Pathways Linking Cannabidiol, Hemp Seed Oil and Black Sesame Oil in Hyperarousal Insomnia: A Narrative Review |
| Black Seed Sleep Meta-Analysis | The consequences of insufficient sleep also extend into psychological and occupational domains, where disrupted sleep has been associated with reduced emotional resilience, increased depression risk, and errors in high-stakes professional environments [,,]. | 4 | Kovitkanit Piphat (2026) | Mechanistic Pathways Linking Cannabidiol, Hemp Seed Oil and Black Sesame Oil in Hyperarousal Insomnia: A Narrative Review |
| Black Seed Sleep Meta-Analysis | Recent international sleep medicine guidelines continue to emphasize the clinical significance of insomnia as a prevalent and burdensome condition requiring evidence-based management []. | 4 | Kovitkanit Piphat (2026) | Mechanistic Pathways Linking Cannabidiol, Hemp Seed Oil and Black Sesame Oil in Hyperarousal Insomnia: A Narrative Review |
| Black Seed Sleep Meta-Analysis | 1 2 3 3 4 5 6 7 8 Poor sleep has wide-ranging physiological, neurological, and psychological consequences, motivating investigation into the upstream biological pathways underlying disturbances in sleep regulation [,,]. | 4 | Kovitkanit Piphat (2026) | Mechanistic Pathways Linking Cannabidiol, Hemp Seed Oil and Black Sesame Oil in Hyperarousal Insomnia: A Narrative Review |
Source documents