topicBlack Cumin Seed Sleep Randomized Trial
claimNon-pharmacological complementary and alternative medicine (CAM) approaches are widely used in KOA care, but randomized controlled trial (RCT) evidence is distributed across diverse intervention types, settings, comparators, and outcome measures.
evidence level2
citationKang Y (2026)
sourceNon-Pharmacological Complementary and Alternative Therapies for Knee Osteoarthritis: A Scoping Review of Randomized Controlled Trials.
topicBlack Cumin Seed Sleep Randomized Trial
claimMethods Following the Arksey and O'Malley scoping review framework and the PRISMA-ScR reporting guideline, we searched PubMed, Web of Science, Embase, and the Cochrane Library for RCTs published from 1 January 2016 to 10 January 2026.
evidence level2
citationKang Y (2026)
sourceNon-Pharmacological Complementary and Alternative Therapies for Knee Osteoarthritis: A Scoping Review of Randomized Controlled Trials.
topicBlack Cumin Seed Sleep Randomized Trial
claimEvidence was summarized descriptively and narratively; no pooled treatment-effect estimates were calculated.
evidence level2
citationKang Y (2026)
sourceNon-Pharmacological Complementary and Alternative Therapies for Knee Osteoarthritis: A Scoping Review of Randomized Controlled Trials.
topicBlack Cumin Seed Sleep Randomized Trial
claimBackground Knee osteoarthritis (KOA) is a prevalent chronic degenerative joint disorder and a major contributor to pain, disability, and impaired quality of life.
evidence level2
citationKang Y (2026)
sourceNon-Pharmacological Complementary and Alternative Therapies for Knee Osteoarthritis: A Scoping Review of Randomized Controlled Trials.
topicBlack Cumin Seed Sleep Randomized Trial
claimThese disturbances occur despite adequate opportunity and conditions for sleep [], and they result in general dissatisfaction with sleep quality and various daytime impairments.
evidence level3
citationŻełabowski Kacper (2025)
sourceThe Efficacy of Melatonergic Receptor Agonists Used in Clinical Practice in Insomnia Treatment: Melatonin, Tasimelteon, Ramelteon, Agomelatine, and Selected Herbs
topicBlack Cumin Seed Sleep Randomized Trial
claimIndividuals reporting nighttime symptoms without associated daytime dysfunction are not classified as having clinical insomnia [,].
evidence level3
citationŻełabowski Kacper (2025)
sourceThe Efficacy of Melatonergic Receptor Agonists Used in Clinical Practice in Insomnia Treatment: Melatonin, Tasimelteon, Ramelteon, Agomelatine, and Selected Herbs
topicBlack Cumin Seed Sleep Randomized Trial
claimStudies have demonstrated a direct correlation between inadequate sleep and an increased risk of developing metabolic diseases, such as diabetes, obesity, hypertension, cardiovascular disease, and depression [,,].
evidence level3
citationŻełabowski Kacper (2025)
sourceThe Efficacy of Melatonergic Receptor Agonists Used in Clinical Practice in Insomnia Treatment: Melatonin, Tasimelteon, Ramelteon, Agomelatine, and Selected Herbs
topicBlack Cumin Seed Sleep Randomized Trial
claim1 2 2 3 4 3 5 6 6 4 6 The etymology of the term “insomnia” derives from Latin, combining “in” meaning “not” and “somnus,” meaning “sleep” [].
evidence level3
citationŻełabowski Kacper (2025)
sourceThe Efficacy of Melatonergic Receptor Agonists Used in Clinical Practice in Insomnia Treatment: Melatonin, Tasimelteon, Ramelteon, Agomelatine, and Selected Herbs