topicAlpha-Lipoic Acid Blood Pressure Meta-Analysis
claimA random-effects meta-analysis using the REML estimator was applied to calculate relative risk (RR), including continuity corrections for zero-event studies.
evidence level1
citationPena E (2026)
sourceSystematic review and meta-analysis of antioxidant treatment in patients with acute mountain sickness induced by high altitude exposure.
topicAlpha-Lipoic Acid Blood Pressure Meta-Analysis
claimData extraction was performed in duplicate, and risk of bias was evaluated using the Cochrane tool.
evidence level1
citationPena E (2026)
sourceSystematic review and meta-analysis of antioxidant treatment in patients with acute mountain sickness induced by high altitude exposure.
topicAlpha-Lipoic Acid Blood Pressure Meta-Analysis
claimPooled estimates showed a non-significant trend toward reduced AMS incidence with antioxidant treatment (RR ≈ 0.73; 95% CI: 0.47-1.11; p = 0.14).
evidence level1
citationPena E (2026)
sourceSystematic review and meta-analysis of antioxidant treatment in patients with acute mountain sickness induced by high altitude exposure.
topicAlpha-Lipoic Acid Blood Pressure Meta-Analysis
claimAcute Mountain Sickness (AMS) is a frequent condition triggered by exposure to hypobaric hypoxia at high altitude.
evidence level1
citationPena E (2026)
sourceSystematic review and meta-analysis of antioxidant treatment in patients with acute mountain sickness induced by high altitude exposure.
topicAlpha-Lipoic Acid Blood Pressure Meta-Analysis
claimExperimental data and clinical studies highlight the cardiometabolic changes associated with gonadal aging and reproductive hormones’ withdrawal [].
evidence level3
citationKaraflou Maria (2026)
sourceAntioxidants in Menopausal Transition and Male Late-Onset Hypogonadism for the Prevention of Diabetes
topicAlpha-Lipoic Acid Blood Pressure Meta-Analysis
claimBody composition changes with increased fat mass and abdominal fat distribution are associated with insulin resistance and subsequent diabetes in older ages [,].
evidence level3
citationKaraflou Maria (2026)
sourceAntioxidants in Menopausal Transition and Male Late-Onset Hypogonadism for the Prevention of Diabetes
topicAlpha-Lipoic Acid Blood Pressure Meta-Analysis
claim5 6 7 Oxidative stress is closely associated with conditions that predispose individuals to T2DM, including obesity.
evidence level3
citationKaraflou Maria (2026)
sourceAntioxidants in Menopausal Transition and Male Late-Onset Hypogonadism for the Prevention of Diabetes
topicAlpha-Lipoic Acid Blood Pressure Meta-Analysis
claim1 1 2 www.pubmed.gov Menopause and male late-onset hypogonadism (LOH) are well-described transitions in females and males during their lifespan.
evidence level3
citationKaraflou Maria (2026)
sourceAntioxidants in Menopausal Transition and Male Late-Onset Hypogonadism for the Prevention of Diabetes