Structured evidence table for Alpha Lipoic Acid Blood Glucose Meta-Analysis, generated from 4 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Alpha Lipoic Acid Blood Glucose Meta-Analysis | Experimental data and clinical studies highlight the cardiometabolic changes associated with gonadal aging and reproductive hormones’ withdrawal []. | 3 | Karaflou Maria (2026) | Antioxidants in Menopausal Transition and Male Late-Onset Hypogonadism for the Prevention of Diabetes |
| Alpha Lipoic Acid Blood Glucose Meta-Analysis | Body composition changes with increased fat mass and abdominal fat distribution are associated with insulin resistance and subsequent diabetes in older ages [,]. | 3 | Karaflou Maria (2026) | Antioxidants in Menopausal Transition and Male Late-Onset Hypogonadism for the Prevention of Diabetes |
| Alpha Lipoic Acid Blood Glucose Meta-Analysis | 5 6 7 Oxidative stress is closely associated with conditions that predispose individuals to T2DM, including obesity. | 3 | Karaflou Maria (2026) | Antioxidants in Menopausal Transition and Male Late-Onset Hypogonadism for the Prevention of Diabetes |
| Alpha Lipoic Acid Blood Glucose Meta-Analysis | 1 1 2 www.pubmed.gov Menopause and male late-onset hypogonadism (LOH) are well-described transitions in females and males during their lifespan. | 3 | Karaflou Maria (2026) | Antioxidants in Menopausal Transition and Male Late-Onset Hypogonadism for the Prevention of Diabetes |
| Alpha Lipoic Acid Blood Glucose Meta-Analysis | This review critically evaluates the mechanistic rationale and clinical evidence for alpha-lipoic acid (ALA) and benfotiamine as adjunctive treatments for DPN. | 4 | Ciubotaru A (2026) | Alpha-Lipoic Acid and Benfotiamine in Diabetic Peripheral Neuropathy: A Critical Review of Mechanistic Rationale and Clinical Evidence Within a Nutritional Therapeutic Framework. |
| Alpha Lipoic Acid Blood Glucose Meta-Analysis | Evidence was synthesized qualitatively with emphasis on mechanistic plausibility, clinical efficacy, intervention duration, and methodological rigor. | 4 | Ciubotaru A (2026) | Alpha-Lipoic Acid and Benfotiamine in Diabetic Peripheral Neuropathy: A Critical Review of Mechanistic Rationale and Clinical Evidence Within a Nutritional Therapeutic Framework. |
| Alpha Lipoic Acid Blood Glucose Meta-Analysis | The long-term NATHAN 1 trial reported a marginal, borderline significant effect on the primary composite endpoint (NIS-LL, p = 0.05) without significant improvements in nerve conduction studies; therefore, evidence for functional stabilization is very limited and inconclusive. | 4 | Ciubotaru A (2026) | Alpha-Lipoic Acid and Benfotiamine in Diabetic Peripheral Neuropathy: A Critical Review of Mechanistic Rationale and Clinical Evidence Within a Nutritional Therapeutic Framework. |
| Alpha Lipoic Acid Blood Glucose Meta-Analysis | Background Diabetic peripheral neuropathy (DPN) affects up to 50% of diabetes patients and is driven by hyperglycemia-induced oxidative stress, mitochondrial dysfunction, polyol pathway activation, advanced glycation end-product formation, and inflammation. | 4 | Ciubotaru A (2026) | Alpha-Lipoic Acid and Benfotiamine in Diabetic Peripheral Neuropathy: A Critical Review of Mechanistic Rationale and Clinical Evidence Within a Nutritional Therapeutic Framework. |
| Alpha Lipoic Acid Blood Glucose Meta-Analysis | T2DM is primarily characterized by insulin resistance, a pathological condition in which target tissues exhibit a reduced response to insulin, a hormone essential for glucose regulation and uptake (Ahmad et al. ). | 4 | Ko Chih‐Yuan (2026) | Alpha‐Lipoic Acid Reduces NLRP3 / ASC Expression and IL ‐1β Release in Kupffer Cells and Improves Insulin Signaling in FL83B Hepatocytes Exposed to a Conditioned Medium |
| Alpha Lipoic Acid Blood Glucose Meta-Analysis | 2025 2011 2011 2023 2016 2016 2025 A growing body of evidence supports the notion that oxidative stress and chronic low‐grade inflammation are fundamental contributors to the pathogenesis of insulin resistance (Juzbašić et al. ; Rains and Jain ). | 4 | Ko Chih‐Yuan (2026) | Alpha‐Lipoic Acid Reduces NLRP3 / ASC Expression and IL ‐1β Release in Kupffer Cells and Improves Insulin Signaling in FL83B Hepatocytes Exposed to a Conditioned Medium |
| Alpha Lipoic Acid Blood Glucose Meta-Analysis | 2023 2025 2013 2019 2021 2023 2024 2001 2019 2024 Alpha‐lipoic acid (ALA) is a naturally occurring disulfide compound found in various animal‐ and plant‐based foods. | 4 | Ko Chih‐Yuan (2026) | Alpha‐Lipoic Acid Reduces NLRP3 / ASC Expression and IL ‐1β Release in Kupffer Cells and Improves Insulin Signaling in FL83B Hepatocytes Exposed to a Conditioned Medium |
| Alpha Lipoic Acid Blood Glucose Meta-Analysis | 2021 2022 2021 Type 2 diabetes mellitus (T2DM) has become an increasingly important global health issue. | 4 | Ko Chih‐Yuan (2026) | Alpha‐Lipoic Acid Reduces NLRP3 / ASC Expression and IL ‐1β Release in Kupffer Cells and Improves Insulin Signaling in FL83B Hepatocytes Exposed to a Conditioned Medium |
Source documents