Is Theacrine Cognition Randomized Trial safe?

Updated October 2026

Quick Answer

Theacrine Cognition Randomized Trial has evidence relevant to safety, limits, and clinician-discussion contexts, but conclusions should stay close to the cited sources. One representative finding is: Results Compared to pre-dose, CDT improved performance on the Flanker Test of Inhibitory Control and improved reaction time on the Psychomotor Vigilance Task post-dose.

Key Takeaways

  • 01Results Compared to pre-dose, CDT improved performance on the Flanker Test of Inhibitory Control and improved reaction time on the Psychomotor Vigilance Task post-dose. [Tartar JL (2021)]
  • 02Compared to the placebo, caffeine increased self-reported anxiety whereas the CDT combination increased self-reported alertness. [Tartar JL (2021)]
  • 03Physiological measures suggested that increases in delta EEG power and cortisol production are associated with the effects observed in the CDT condition to optimize certain aspects of egamer performance. [Tartar JL (2021)]
  • 04Background Involvement in video game activities and competitive video gaming (esports) is a rapidly growing field. [Tartar JL (2021)]
The current Migaku evidence database contains 1 reusable source document for Theacrine Cognition Randomized Trial. This answer focuses on safety, limits, and clinician-discussion contexts. - Results Compared to pre-dose, CDT improved performance on the Flanker Test of Inhibitory Control and improved reaction time on the Psychomotor Vigilance Task post-dose. [Tartar JL (2021); evidence level 4] - Compared to the placebo, caffeine increased self-reported anxiety whereas the CDT combination increased self-reported alertness. [Tartar JL (2021); evidence level 4] - Physiological measures suggested that increases in delta EEG power and cortisol production are associated with the effects observed in the CDT condition to optimize certain aspects of egamer performance. [Tartar JL (2021); evidence level 4] - Background Involvement in video game activities and competitive video gaming (esports) is a rapidly growing field. [Tartar JL (2021); evidence level 4] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.

Sources

  1. A Combination of Caffeine, TeaCrine® (Theacrine), and Dynamine® (Methylliberine) Increases Cognitive Performance and Reaction Time Without Interfering With Mood in Adult Male Egamers.