cognition

Baicalin Cognition Randomized Trial Evidence Table

Structured evidence table for Baicalin Cognition Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Baicalin Cognition Randomized Trial1 2 3 4 Ischemic stroke accounts for approximately 87% of all reported stroke cases and is frequently associated with cognitive dysfunction [,].4Liu Jianfeng (2020)Baicalin ameliorates neuropathology in repeated cerebral ischemia-reperfusion injury model mice by remodeling the gut microbiota
Baicalin Cognition Randomized TrialIn the mouse model of cerebral hypoperfusion, consumption of multistrain probiotics can alleviate hippocampal injury and deficits in spatial and learning memory, thereby providing more evidence for the key role of gut microbiota in brain function [].4Liu Jianfeng (2020)Baicalin ameliorates neuropathology in repeated cerebral ischemia-reperfusion injury model mice by remodeling the gut microbiota
Baicalin Cognition Randomized TrialFigure 1A Figure 1B 1C Figure 1D Figure 1E Figure 1F 1G The object recognition test results showed that the preferential index after training for 1h was significantly reduced in the mice subjected to repeated cerebral ischemia-reperfusion (model group) compared with the control mice ().4Liu Jianfeng (2020)Baicalin ameliorates neuropathology in repeated cerebral ischemia-reperfusion injury model mice by remodeling the gut microbiota
Baicalin Cognition Randomized TrialCurrently, the standard treatment for acute ischemic stroke is intravenous thrombolytic therapy with recombinant tissue plasminogen activator (rt-PA) [].4Liu Jianfeng (2020)Baicalin ameliorates neuropathology in repeated cerebral ischemia-reperfusion injury model mice by remodeling the gut microbiota
Baicalin Cognition Randomized TrialConclusion Overall, the results of the present study indicated that BAI is a promising neuroprotective compound for use in the prevention and treatment of microglia-mediated neuroinflammation during AD progression.4Jin X (2019)Baicalin mitigates cognitive impairment and protects neurons from microglia-mediated neuroinflammation via suppressing NLRP3 inflammasomes and TLR4/NF-κB signaling pathway.
Baicalin Cognition Randomized TrialAims Baicalin (BAI), a flavonoid compound isolated from the root of Scutellaria baicalensis Georgi, has been established to have potent anti-inflammation and neuroprotective properties; however, its effects during Alzheimer's disease (AD) treatment have not been well studied.4Jin X (2019)Baicalin mitigates cognitive impairment and protects neurons from microglia-mediated neuroinflammation via suppressing NLRP3 inflammasomes and TLR4/NF-κB signaling pathway.
Baicalin Cognition Randomized TrialThis study aimed to investigate the effects of BAI pretreatment on cognitive impairment and neuronal protection against microglia-induced neuroinflammation and to explore the mechanisms underlying its anti-inflammation effects.4Jin X (2019)Baicalin mitigates cognitive impairment and protects neurons from microglia-mediated neuroinflammation via suppressing NLRP3 inflammasomes and TLR4/NF-κB signaling pathway.
topicBaicalin Cognition Randomized Trial
claim1 2 3 4 Ischemic stroke accounts for approximately 87% of all reported stroke cases and is frequently associated with cognitive dysfunction [,].
evidence level4
citationLiu Jianfeng (2020)
sourceBaicalin ameliorates neuropathology in repeated cerebral ischemia-reperfusion injury model mice by remodeling the gut microbiota
topicBaicalin Cognition Randomized Trial
claimIn the mouse model of cerebral hypoperfusion, consumption of multistrain probiotics can alleviate hippocampal injury and deficits in spatial and learning memory, thereby providing more evidence for the key role of gut microbiota in brain function [].
evidence level4
citationLiu Jianfeng (2020)
sourceBaicalin ameliorates neuropathology in repeated cerebral ischemia-reperfusion injury model mice by remodeling the gut microbiota
topicBaicalin Cognition Randomized Trial
claimFigure 1A Figure 1B 1C Figure 1D Figure 1E Figure 1F 1G The object recognition test results showed that the preferential index after training for 1h was significantly reduced in the mice subjected to repeated cerebral ischemia-reperfusion (model group) compared with the control mice ().
evidence level4
citationLiu Jianfeng (2020)
sourceBaicalin ameliorates neuropathology in repeated cerebral ischemia-reperfusion injury model mice by remodeling the gut microbiota
topicBaicalin Cognition Randomized Trial
claimCurrently, the standard treatment for acute ischemic stroke is intravenous thrombolytic therapy with recombinant tissue plasminogen activator (rt-PA) [].
evidence level4
citationLiu Jianfeng (2020)
sourceBaicalin ameliorates neuropathology in repeated cerebral ischemia-reperfusion injury model mice by remodeling the gut microbiota
topicBaicalin Cognition Randomized Trial
claimConclusion Overall, the results of the present study indicated that BAI is a promising neuroprotective compound for use in the prevention and treatment of microglia-mediated neuroinflammation during AD progression.
evidence level4
citationJin X (2019)
sourceBaicalin mitigates cognitive impairment and protects neurons from microglia-mediated neuroinflammation via suppressing NLRP3 inflammasomes and TLR4/NF-κB signaling pathway.
topicBaicalin Cognition Randomized Trial
claimAims Baicalin (BAI), a flavonoid compound isolated from the root of Scutellaria baicalensis Georgi, has been established to have potent anti-inflammation and neuroprotective properties; however, its effects during Alzheimer's disease (AD) treatment have not been well studied.
evidence level4
citationJin X (2019)
sourceBaicalin mitigates cognitive impairment and protects neurons from microglia-mediated neuroinflammation via suppressing NLRP3 inflammasomes and TLR4/NF-κB signaling pathway.
topicBaicalin Cognition Randomized Trial
claimThis study aimed to investigate the effects of BAI pretreatment on cognitive impairment and neuronal protection against microglia-induced neuroinflammation and to explore the mechanisms underlying its anti-inflammation effects.
evidence level4
citationJin X (2019)
sourceBaicalin mitigates cognitive impairment and protects neurons from microglia-mediated neuroinflammation via suppressing NLRP3 inflammasomes and TLR4/NF-κB signaling pathway.

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Source documents

  1. Baicalin ameliorates neuropathology in repeated cerebral ischemia-reperfusion injury model mice by remodeling the gut microbiota
  2. Baicalin mitigates cognitive impairment and protects neurons from microglia-mediated neuroinflammation via suppressing NLRP3 inflammasomes and TLR4/NF-κB signaling pathway.