evidence answer

Is Sodium Bicarbonate Endurance Performance Randomized Trial safe?

Updated July 2026

Quick Answer

Sodium Bicarbonate Endurance Performance Randomized Trial has evidence relevant to safety, limits, and clinician-discussion contexts, but conclusions should stay close to the cited sources. One representative finding is: Two reviewers independently performed literature screening, data extraction, and risk of bias assessment using the Cochrane RoB 2.0 tool.

Key Takeaways

  • 01Two reviewers independently performed literature screening, data extraction, and risk of bias assessment using the Cochrane RoB 2.0 tool. [Zhu Y (2026)]
  • 02Conclusion The interventional efficacy of menthol in the heat appears to be co-regulated by the administration route and the specific exercise task. [Zhu Y (2026)]
  • 03While the current evidence does not establish definitive superiority among the administration routes due to the lack of statistical significance, ingestion may serve as an exploratory option for long-duration endurance events, whereas mouth rinsing could be considered for tasks focusing on instantaneous power output. [Zhu Y (2026)]
  • 04Objective This study employed a network meta-analysis (NMA) to systematically evaluate and compare the relative efficacy of three menthol administration routes-ingestion (ING), mouth rinsing (MR), and topical application (Top)-on exercise performance and physiological responses in the heat, aiming to explore potential task-oriented personalized supplementation strategies. [Zhu Y (2026)]
The current Migaku evidence database contains 2 reusable source documents for Sodium Bicarbonate Endurance Performance Randomized Trial. This answer focuses on safety, limits, and clinician-discussion contexts. - Two reviewers independently performed literature screening, data extraction, and risk of bias assessment using the Cochrane RoB 2.0 tool. [Zhu Y (2026); evidence level 1] - Conclusion The interventional efficacy of menthol in the heat appears to be co-regulated by the administration route and the specific exercise task. [Zhu Y (2026); evidence level 1] - While the current evidence does not establish definitive superiority among the administration routes due to the lack of statistical significance, ingestion may serve as an exploratory option for long-duration endurance events, whereas mouth rinsing could be considered for tasks focusing on instantaneous power output. [Zhu Y (2026); evidence level 1] - Objective This study employed a network meta-analysis (NMA) to systematically evaluate and compare the relative efficacy of three menthol administration routes-ingestion (ING), mouth rinsing (MR), and topical application (Top)-on exercise performance and physiological responses in the heat, aiming to explore potential task-oriented personalized supplementation strategies. [Zhu Y (2026); evidence level 1] - No significant differences were found under any condition for RPE, EMG, and KE repetitions. [Williams MLA (2025); evidence level 4] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.

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Sources

  1. Effects of different menthol administration routes on endurance performance and physiological responses in the heat: a network meta-analysis.
  2. No Ergogenic Effect of Caffeine or Sodium Bicarbonate on Resistance Exercise Performance: A Double-Blind Crossover Study with Sex-Based Analysis.