Is Sodium Bicarbonate Endurance Meta-Analysis safe?

The current Migaku evidence database contains 2 reusable source documents for Sodium Bicarbonate Endurance Meta-Analysis. This answer focuses on safety, limits, and clinician-discussion contexts. - Risk of bias was assessed using the Cochrane Risk of Bias 2 (RoB 2) tool, and certainty of evidence was evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. [Ge X (2026); evidence level 1] - NaHCO3 ingestion increased post-exercise blood lactate (MD = 1.73 mmol/L, 95% CI: 0.97 to 2.49), HCO3- (MD = 2.73 mmol/L, 95% CI: 2.16 to 3.30), and pH (MD = 0.050, 95% CI: 0.025 to 0.075). [Ge X (2026); evidence level 1] - Certainty of evidence was low for HIIE performance and HCO3- and very low for blood lactate and pH. [Ge X (2026); evidence level 1] - Background Sodium bicarbonate (NaHCO3) ingestion can induce extracellular alkalosis, but its effects on high-intensity intermittent exercise (HIIE) performance in team sports remain unclear. [Ge X (2026); evidence level 1] - However, comparisons among active conditions provided no clear evidence that co-ingestion was superior to either supplement alone. [Liu S (2026); evidence level 1] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.