topicSodium Bicarbonate Endurance Meta-Analysis
claimRisk of bias was assessed using the Cochrane Risk of Bias 2 (RoB 2) tool, and certainty of evidence was evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.
evidence level1
citationGe X (2026)
sourceEffects of acute or short-term oral sodium bicarbonate supplementation on high-intensity intermittent exercise performance and physiological responses in team-sport athletes: a systematic review and meta-analysis.
topicSodium Bicarbonate Endurance Meta-Analysis
claimNaHCO3 ingestion increased post-exercise blood lactate (MD = 1.73 mmol/L, 95% CI: 0.97 to 2.49), HCO3- (MD = 2.73 mmol/L, 95% CI: 2.16 to 3.30), and pH (MD = 0.050, 95% CI: 0.025 to 0.075).
evidence level1
citationGe X (2026)
sourceEffects of acute or short-term oral sodium bicarbonate supplementation on high-intensity intermittent exercise performance and physiological responses in team-sport athletes: a systematic review and meta-analysis.
topicSodium Bicarbonate Endurance Meta-Analysis
claimCertainty of evidence was low for HIIE performance and HCO3- and very low for blood lactate and pH.
evidence level1
citationGe X (2026)
sourceEffects of acute or short-term oral sodium bicarbonate supplementation on high-intensity intermittent exercise performance and physiological responses in team-sport athletes: a systematic review and meta-analysis.
topicSodium Bicarbonate Endurance Meta-Analysis
claimBackground Sodium bicarbonate (NaHCO3) ingestion can induce extracellular alkalosis, but its effects on high-intensity intermittent exercise (HIIE) performance in team sports remain unclear.
evidence level1
citationGe X (2026)
sourceEffects of acute or short-term oral sodium bicarbonate supplementation on high-intensity intermittent exercise performance and physiological responses in team-sport athletes: a systematic review and meta-analysis.
topicSodium Bicarbonate Endurance Meta-Analysis
claimHowever, comparisons among active conditions provided no clear evidence that co-ingestion was superior to either supplement alone.
evidence level1
citationLiu S (2026)
sourceIndividual and Combined Effects of Acute Caffeine and Sodium Bicarbonate Supplementation on Exercise Performance and Metabolic Responses: A Bayesian Network Meta-Analysis of Co-Supplementation Trials.
topicSodium Bicarbonate Endurance Meta-Analysis
claimSB increased blood pH (g = 0.95) and blood lactate (g = 1.13), whereas caffeine reduced blood bicarbonate (g = -0.89).
evidence level1
citationLiu S (2026)
sourceIndividual and Combined Effects of Acute Caffeine and Sodium Bicarbonate Supplementation on Exercise Performance and Metabolic Responses: A Bayesian Network Meta-Analysis of Co-Supplementation Trials.
topicSodium Bicarbonate Endurance Meta-Analysis
claimBackground : Caffeine and sodium bicarbonate (SB) are widely used ergogenic supplements that influence exercise performance through distinct physiological mechanisms and may differentially modulate exercise-related metabolic responses.
evidence level1
citationLiu S (2026)
sourceIndividual and Combined Effects of Acute Caffeine and Sodium Bicarbonate Supplementation on Exercise Performance and Metabolic Responses: A Bayesian Network Meta-Analysis of Co-Supplementation Trials.
topicSodium Bicarbonate Endurance Meta-Analysis
claimWhether their co-ingestion provides benefits beyond either supplement alone remains uncertain.
evidence level1
citationLiu S (2026)
sourceIndividual and Combined Effects of Acute Caffeine and Sodium Bicarbonate Supplementation on Exercise Performance and Metabolic Responses: A Bayesian Network Meta-Analysis of Co-Supplementation Trials.