Quick Answer
Purple Grape Juice Cognition Randomized Trial has evidence relevant to safety, limits, and clinician-discussion contexts, but conclusions should stay close to the cited sources. One representative finding is: 1 2 3 4 5 6 8 9 10 9 10 Vitis labrusca Phenolic compounds are found in varying concentrations in a range of plant-based food sources, such as legumes, fruit, vegetables, herbal extracts, spices, coffee, tea and cocoa.
Key Takeaways
- 011 2 3 4 5 6 8 9 10 9 10 Vitis labrusca Phenolic compounds are found in varying concentrations in a range of plant-based food sources, such as legumes, fruit, vegetables, herbal extracts, spices, coffee, tea and cocoa. [Haskell-Ramsay C. F. (2017)]
- 02Berry fruits, such as strawberry, blueberry, blackcurrant and grape, represent a rich source of (poly)phenols, which are linked to a number of health benefits including modulation of inflammation [,], reductions in risk of cardiovascular disease (see [] for systematic review), anti-cancer effects [], and protection against neurodegenerative diseases [–]. [Haskell-Ramsay C. F. (2017)]
- 03These are supported by evidence of a number of potential direct and indirect mechanisms, including their interaction with gut microbiota [], modulation of neuroinflammation [], improved cerebrovascular function (reviewed in []), modulation of glucoregulation [] and increased spine density and neurogenesis, particularly in the hippocampus []. [Haskell-Ramsay C. F. (2017)]
- 04These compounds are grouped into phenolic acids, stilbenes, lignans and flavonoids on the basis of the number of phenol rings; with flavonoids further sub-classified into flavonols, flavones, isoflavones, flavanones, anthocyanidins and flavan-3-ols as a function of their structural complexity []. [Haskell-Ramsay C. F. (2017)]
The current Migaku evidence database contains 1 reusable source document for Purple Grape Juice Cognition Randomized Trial. This answer focuses on safety, limits, and clinician-discussion contexts.
- 1 2 3 4 5 6 8 9 10 9 10 Vitis labrusca Phenolic compounds are found in varying concentrations in a range of plant-based food sources, such as legumes, fruit, vegetables, herbal extracts, spices, coffee, tea and cocoa. [Haskell-Ramsay C. F. (2017); evidence level 4]
- Berry fruits, such as strawberry, blueberry, blackcurrant and grape, represent a rich source of (poly)phenols, which are linked to a number of health benefits including modulation of inflammation [,], reductions in risk of cardiovascular disease (see [] for systematic review), anti-cancer effects [], and protection against neurodegenerative diseases [–]. [Haskell-Ramsay C. F. (2017); evidence level 4]
- These are supported by evidence of a number of potential direct and indirect mechanisms, including their interaction with gut microbiota [], modulation of neuroinflammation [], improved cerebrovascular function (reviewed in []), modulation of glucoregulation [] and increased spine density and neurogenesis, particularly in the hippocampus []. [Haskell-Ramsay C. F. (2017); evidence level 4]
- These compounds are grouped into phenolic acids, stilbenes, lignans and flavonoids on the basis of the number of phenol rings; with flavonoids further sub-classified into flavonols, flavones, isoflavones, flavanones, anthocyanidins and flavan-3-ols as a function of their structural complexity []. [Haskell-Ramsay C. F. (2017); evidence level 4]
Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording.
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