topicGrape Polyphenols Cognition Randomized Trial
claimis rich in polyphenols and oligomeric proanthocyanidin complexes (OPCs), and it has shown potential benefits in managing low mood and cognitive function.
evidence level4
citationHasbal-Celikok G (2024)
sourceIn Vitro Mechanistic Studies of a Standardized Sustainable Grape Seed Extract for Potential Application as a Mood-Modulating and Cognition-Enhancing Supplement.
topicGrape Polyphenols Cognition Randomized Trial
claimIn this study, we investigated the potential bioactivities of Enovita ® , a standardized GSE extract (GSEe herein) rich in OPCs, in key mechanistic pathways related to low mood conditions and cognitive function.
evidence level4
citationHasbal-Celikok G (2024)
sourceIn Vitro Mechanistic Studies of a Standardized Sustainable Grape Seed Extract for Potential Application as a Mood-Modulating and Cognition-Enhancing Supplement.
topicGrape Polyphenols Cognition Randomized Trial
claimBased on the RNA-Seq analysis, genetic expression in the brain varied as a result of diet, with 210, 360, and 221 uniquely expressed genes in the STD, HFD, and HF1G groups, respectively.
evidence level4
citationParande F (2022)
sourceEffect of Dietary Grapes on Female C57BL6/J Mice Consuming a High-Fat Diet: Behavioral and Genetic Changes.
topicGrape Polyphenols Cognition Randomized Trial
claimFocusing on some specific areas, based on genetic expression, Dopamine receptor 2 (Drd2) was increased in the HFD group and normalized in the HF1G group, relative to the STD group.
evidence level4
citationParande F (2022)
sourceEffect of Dietary Grapes on Female C57BL6/J Mice Consuming a High-Fat Diet: Behavioral and Genetic Changes.
topicGrape Polyphenols Cognition Randomized Trial
claimIn addition, as judged by cluster hierarchy, the expression of genes that are associated with the dopamine receptor 2 pathway were increased in the HFD group, whereas the pattern that was derived from mouse brain from the HF1G group showed greater similarity to the STD group.
evidence level4
citationParande F (2022)
sourceEffect of Dietary Grapes on Female C57BL6/J Mice Consuming a High-Fat Diet: Behavioral and Genetic Changes.
topicGrape Polyphenols Cognition Randomized Trial
claim(1) Background: Adverse effects of a chronic high-fat diet (HFD) on murine behavior, cognition, and memory are well established.
evidence level4
citationParande F (2022)
sourceEffect of Dietary Grapes on Female C57BL6/J Mice Consuming a High-Fat Diet: Behavioral and Genetic Changes.