skin aging

Does Polypodium Leucotomos Skin Photoprotection Randomized Trial work?

Updated October 2026

Quick Answer

Polypodium Leucotomos Skin Photoprotection Randomized Trial has evidence relevant to strength of evidence and what the studies can or cannot prove, but conclusions should stay close to the cited sources. One representative finding is: Results : Throughout the intervention, MED gradually increased, while Δ a* decreased in the IP group.

Key Takeaways

  • 01Results : Throughout the intervention, MED gradually increased, while Δ a* decreased in the IP group. [Keršmanc P (2025)]
  • 02Background/Objectives : Oral photoprotection is gaining attention as a complementary approach to conventional sun protection. [Keršmanc P (2025)]
  • 03This randomized double-blind placebo-controlled study evaluated the effects of an 8-week dietary intervention with a syrup supplement containing Polypodium leucotomos extract (PLE), Red Orange Extract (ROE), and vitamins A, C, D, and E on minimal erythema dose (MED), UVB-induced erythema (Δ a* ), and pigmentation changes (ΔMI). [Keršmanc P (2025)]
The current Migaku evidence database contains 1 reusable source document for Polypodium Leucotomos Skin Photoprotection Randomized Trial. This answer focuses on strength of evidence and what the studies can or cannot prove. - Results : Throughout the intervention, MED gradually increased, while Δ a* decreased in the IP group. [Keršmanc P (2025); evidence level 2] - Background/Objectives : Oral photoprotection is gaining attention as a complementary approach to conventional sun protection. [Keršmanc P (2025); evidence level 2] - This randomized double-blind placebo-controlled study evaluated the effects of an 8-week dietary intervention with a syrup supplement containing Polypodium leucotomos extract (PLE), Red Orange Extract (ROE), and vitamins A, C, D, and E on minimal erythema dose (MED), UVB-induced erythema (Δ a* ), and pigmentation changes (ΔMI). [Keršmanc P (2025); evidence level 2] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.

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Sources

  1. Effects of Eight-Week Supplementation Containing Red Orange and <i>Polypodium leucotomos</i> Extracts on UVB-Induced Skin Responses: A Randomized Double-Blind Placebo-Controlled Trial.