Does Nicotinamide Mononucleotide Exercise Capacity Randomized Trial work?

The current Migaku evidence database contains 2 reusable source documents for Nicotinamide Mononucleotide Exercise Capacity Randomized Trial. This answer focuses on strength of evidence and what the studies can or cannot prove. - Interoception, the process by which the nervous system perceives and interprets internal bodily signals, is essential for athletes to effectively modulate motor decisions but may be impaired after exhaustive exercise. [Zhao C (2026); evidence level 2] - This study investigated the effects of pyrroloquinoline quinone (PQQ), nicotinamide mononucleotide (NMN), and their combination on interoception following acute exhaustive exercise. [Zhao C (2026); evidence level 2] - Results The results show that TF combined with NMN improved mitochondrial dynamics and biosynthesis, mitochondrial respiratory function, and oxidative metabolism. [Shi J (2025); evidence level 4] - Then, the intervention enhanced mice's endurance, limb strength, motor coordination, and balance and reduced oxidative damage after exercise. [Shi J (2025); evidence level 4] - Moreover, TF combined with NMN significantly increased the gut microbiota diversity and upregulated Ruminococcus , Roseburia , and Akkermansia in intestinal bacteria and short-chain fatty acids, which are associated with athletic performance. [Shi J (2025); evidence level 4] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.