topicNicotinamide Mononucleotide Exercise Capacity Randomized Trial
claimInteroception, the process by which the nervous system perceives and interprets internal bodily signals, is essential for athletes to effectively modulate motor decisions but may be impaired after exhaustive exercise.
evidence level2
citationZhao C (2026)
sourceThe effects of pyrroloquinoline quinone and nicotinamide mononucleotide supplementation on interoception following acute exhaustive exercise: a randomised, double-blind, placebo-controlled study.
topicNicotinamide Mononucleotide Exercise Capacity Randomized Trial
claimThis study investigated the effects of pyrroloquinoline quinone (PQQ), nicotinamide mononucleotide (NMN), and their combination on interoception following acute exhaustive exercise.
evidence level2
citationZhao C (2026)
sourceThe effects of pyrroloquinoline quinone and nicotinamide mononucleotide supplementation on interoception following acute exhaustive exercise: a randomised, double-blind, placebo-controlled study.
topicNicotinamide Mononucleotide Exercise Capacity Randomized Trial
claimResults The results show that TF combined with NMN improved mitochondrial dynamics and biosynthesis, mitochondrial respiratory function, and oxidative metabolism.
evidence level4
citationShi J (2025)
sourceEffects of Time-Restricted Fasting-Nicotinamide Mononucleotide Combination on Exercise Capacity via Mitochondrial Activation and Gut Microbiota Modulation.
topicNicotinamide Mononucleotide Exercise Capacity Randomized Trial
claimThen, the intervention enhanced mice's endurance, limb strength, motor coordination, and balance and reduced oxidative damage after exercise.
evidence level4
citationShi J (2025)
sourceEffects of Time-Restricted Fasting-Nicotinamide Mononucleotide Combination on Exercise Capacity via Mitochondrial Activation and Gut Microbiota Modulation.
topicNicotinamide Mononucleotide Exercise Capacity Randomized Trial
claimMoreover, TF combined with NMN significantly increased the gut microbiota diversity and upregulated Ruminococcus , Roseburia , and Akkermansia in intestinal bacteria and short-chain fatty acids, which are associated with athletic performance.
evidence level4
citationShi J (2025)
sourceEffects of Time-Restricted Fasting-Nicotinamide Mononucleotide Combination on Exercise Capacity via Mitochondrial Activation and Gut Microbiota Modulation.
topicNicotinamide Mononucleotide Exercise Capacity Randomized Trial
claimBackground/objectives Athletic performance matters for athletes and fitness enthusiasts.
evidence level4
citationShi J (2025)
sourceEffects of Time-Restricted Fasting-Nicotinamide Mononucleotide Combination on Exercise Capacity via Mitochondrial Activation and Gut Microbiota Modulation.