Quick Answer
Leucine Muscle Recovery Randomized Trial has evidence relevant to safety, limits, and clinician-discussion contexts, but conclusions should stay close to the cited sources. One representative finding is: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Skeletal muscle disuse in older individuals (>65 years old) increases fall risk, hospitalization, and chronic disease development and accelerates age-induced muscle loss (sarcopenia) [,].
Key Takeaways
- 011 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Skeletal muscle disuse in older individuals (>65 years old) increases fall risk, hospitalization, and chronic disease development and accelerates age-induced muscle loss (sarcopenia) [,]. [Petrocelli Jonathan J. (2020)]
- 02Disuse-induced muscle atrophy and weakness and prolonged recovery from disuse in aging contribute to reduced life- and healthspan as skeletal muscle is important for whole-body glucose regulation [], postural stability/balance to prevent falls [], and strength to perform activities of daily living []. [Petrocelli Jonathan J. (2020)]
- 03Below we will present evidence that the SIRT1–AMPKα–PGC-1α signaling axis is targeted by several nutritional and pharmaceutical interventions and thus could be suitable translatable solutions to prevent disuse-induced muscle atrophy and improve recovery from disuse in older adults. [Petrocelli Jonathan J. (2020)]
- 04During recovery from disuse (e.g., surgery, injury, illness), older individuals experience delayed muscle size and strength recovery compared to their younger counterparts [,,,,,], a phenotype recapitulated in aged rodents [,]. [Petrocelli Jonathan J. (2020)]
The current Migaku evidence database contains 2 reusable source documents for Leucine Muscle Recovery Randomized Trial. This answer focuses on safety, limits, and clinician-discussion contexts.
- 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Skeletal muscle disuse in older individuals (>65 years old) increases fall risk, hospitalization, and chronic disease development and accelerates age-induced muscle loss (sarcopenia) [,]. [Petrocelli Jonathan J. (2020); evidence level 3]
- Disuse-induced muscle atrophy and weakness and prolonged recovery from disuse in aging contribute to reduced life- and healthspan as skeletal muscle is important for whole-body glucose regulation [], postural stability/balance to prevent falls [], and strength to perform activities of daily living []. [Petrocelli Jonathan J. (2020); evidence level 3]
- Below we will present evidence that the SIRT1–AMPKα–PGC-1α signaling axis is targeted by several nutritional and pharmaceutical interventions and thus could be suitable translatable solutions to prevent disuse-induced muscle atrophy and improve recovery from disuse in older adults. [Petrocelli Jonathan J. (2020); evidence level 3]
- During recovery from disuse (e.g., surgery, injury, illness), older individuals experience delayed muscle size and strength recovery compared to their younger counterparts [,,,,,], a phenotype recapitulated in aged rodents [,]. [Petrocelli Jonathan J. (2020); evidence level 3]
- [Conclusion] LEAA consumption suppressed exercise-induced elevation of muscle damage markers in blood, which suggests that LEAA could attenuate muscle damage and aid muscle recovery. [Matsui Y (2019); evidence level 4]
Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording.
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Sources