Structured evidence table for Leucine Muscle Recovery Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Leucine Muscle Recovery Randomized Trial | 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Skeletal muscle disuse in older individuals (>65 years old) increases fall risk, hospitalization, and chronic disease development and accelerates age-induced muscle loss (sarcopenia) [,]. | 3 | Petrocelli Jonathan J. (2020) | PGC-1α-Targeted Therapeutic Approaches to Enhance Muscle Recovery in Aging |
| Leucine Muscle Recovery Randomized Trial | Disuse-induced muscle atrophy and weakness and prolonged recovery from disuse in aging contribute to reduced life- and healthspan as skeletal muscle is important for whole-body glucose regulation [], postural stability/balance to prevent falls [], and strength to perform activities of daily living []. | 3 | Petrocelli Jonathan J. (2020) | PGC-1α-Targeted Therapeutic Approaches to Enhance Muscle Recovery in Aging |
| Leucine Muscle Recovery Randomized Trial | Below we will present evidence that the SIRT1–AMPKα–PGC-1α signaling axis is targeted by several nutritional and pharmaceutical interventions and thus could be suitable translatable solutions to prevent disuse-induced muscle atrophy and improve recovery from disuse in older adults. | 3 | Petrocelli Jonathan J. (2020) | PGC-1α-Targeted Therapeutic Approaches to Enhance Muscle Recovery in Aging |
| Leucine Muscle Recovery Randomized Trial | During recovery from disuse (e.g., surgery, injury, illness), older individuals experience delayed muscle size and strength recovery compared to their younger counterparts [,,,,,], a phenotype recapitulated in aged rodents [,]. | 3 | Petrocelli Jonathan J. (2020) | PGC-1α-Targeted Therapeutic Approaches to Enhance Muscle Recovery in Aging |
| Leucine Muscle Recovery Randomized Trial | [Conclusion] LEAA consumption suppressed exercise-induced elevation of muscle damage markers in blood, which suggests that LEAA could attenuate muscle damage and aid muscle recovery. | 4 | Matsui Y (2019) | Effect of a leucine-enriched essential amino acids mixture on muscle recovery. |
| Leucine Muscle Recovery Randomized Trial | [Purpose] The aim of this study was to determine whether the consumption of a leucine-enriched essential amino acid mixture (LEAA), which is known to increase protein synthesis in muscles, alleviates muscle damage and accelerates recovery by ameliorating muscle damage. | 4 | Matsui Y (2019) | Effect of a leucine-enriched essential amino acids mixture on muscle recovery. |
| Leucine Muscle Recovery Randomized Trial | [Participants and Methods] A double-blind, randomized crossover trial was conducted over a 5-week period. | 4 | Matsui Y (2019) | Effect of a leucine-enriched essential amino acids mixture on muscle recovery. |
Source documents