Does L-Theanine Stress Randomized Trial work?

Updated May 2026

Quick Answer

L-Theanine Stress Randomized Trial has evidence relevant to strength of evidence and what the studies can or cannot prove, but conclusions should stay close to the cited sources. One representative finding is: Evidence regarding the acute effects of caffeine (CAF), L-theanine (TEA), and their combination remains inconsistent, particularly with respect to their combined influence on physical and cognitive performance in athletic populations.

Key Takeaways

  • 01Evidence regarding the acute effects of caffeine (CAF), L-theanine (TEA), and their combination remains inconsistent, particularly with respect to their combined influence on physical and cognitive performance in athletic populations. [Tuncer SY (2026)]
  • 02Results Condition effects were found for leg strength ( p = 0.004, ηp 2 = 0.24) and back strength ( p = 0.008, ηp 2 = 0.19). [Tuncer SY (2026)]
  • 03Additionally, no significant difference was found between the conditions in aerobic endurance, maximum isometric handgrip strength, and hand-eye coordination results. [Tuncer SY (2026)]
  • 04Introduction Modern athletic performance is driven not only by physical capacity but also by rapid decision-making, attentional control, and visuomotor coordination. [Tuncer SY (2026)]
The current Migaku evidence database contains 2 reusable source documents for L-Theanine Stress Randomized Trial. This answer focuses on strength of evidence and what the studies can or cannot prove. - Evidence regarding the acute effects of caffeine (CAF), L-theanine (TEA), and their combination remains inconsistent, particularly with respect to their combined influence on physical and cognitive performance in athletic populations. [Tuncer SY (2026); evidence level 2] - Results Condition effects were found for leg strength ( p = 0.004, ηp 2 = 0.24) and back strength ( p = 0.008, ηp 2 = 0.19). [Tuncer SY (2026); evidence level 2] - Additionally, no significant difference was found between the conditions in aerobic endurance, maximum isometric handgrip strength, and hand-eye coordination results. [Tuncer SY (2026); evidence level 2] - Introduction Modern athletic performance is driven not only by physical capacity but also by rapid decision-making, attentional control, and visuomotor coordination. [Tuncer SY (2026); evidence level 2] - Under normal conditions, it is sequestered in the cytoplasm by Kelch-like ECH-associated protein 1 (Keap1), which targets it for degradation []. [Cipriano Giovanni Luca (2026); evidence level 4] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.

Sources

  1. Acute effects of combined and isolated caffeine and theanine supplementation on physical and cognitive performance in competitive athletes: a randomized, double-blind, placebo-controlled crossover study.
  2. Phytochemical and Fungal Bioactive Compounds in the “Brain Health Triad”: A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy