evidence table

L-Theanine Stress Randomized Trial Evidence Table

Structured evidence table for L-Theanine Stress Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
L-Theanine Stress Randomized TrialEvidence regarding the acute effects of caffeine (CAF), L-theanine (TEA), and their combination remains inconsistent, particularly with respect to their combined influence on physical and cognitive performance in athletic populations.2Tuncer SY (2026)Acute effects of combined and isolated caffeine and theanine supplementation on physical and cognitive performance in competitive athletes: a randomized, double-blind, placebo-controlled crossover study.
L-Theanine Stress Randomized TrialResults Condition effects were found for leg strength ( p = 0.004, ηp 2 = 0.24) and back strength ( p = 0.008, ηp 2 = 0.19).2Tuncer SY (2026)Acute effects of combined and isolated caffeine and theanine supplementation on physical and cognitive performance in competitive athletes: a randomized, double-blind, placebo-controlled crossover study.
L-Theanine Stress Randomized TrialAdditionally, no significant difference was found between the conditions in aerobic endurance, maximum isometric handgrip strength, and hand-eye coordination results.2Tuncer SY (2026)Acute effects of combined and isolated caffeine and theanine supplementation on physical and cognitive performance in competitive athletes: a randomized, double-blind, placebo-controlled crossover study.
L-Theanine Stress Randomized TrialIntroduction Modern athletic performance is driven not only by physical capacity but also by rapid decision-making, attentional control, and visuomotor coordination.2Tuncer SY (2026)Acute effects of combined and isolated caffeine and theanine supplementation on physical and cognitive performance in competitive athletes: a randomized, double-blind, placebo-controlled crossover study.
L-Theanine Stress Randomized TrialUnder normal conditions, it is sequestered in the cytoplasm by Kelch-like ECH-associated protein 1 (Keap1), which targets it for degradation [].4Cipriano Giovanni Luca (2026)Phytochemical and Fungal Bioactive Compounds in the “Brain Health Triad”: A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy
L-Theanine Stress Randomized TrialThe following subsections provide a detailed analysis of the molecular profiles and clinical evidence for these three primary bioactives.4Cipriano Giovanni Luca (2026)Phytochemical and Fungal Bioactive Compounds in the “Brain Health Triad”: A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy
L-Theanine Stress Randomized TrialIn elderly patients with mild cognitive impairment (MCI), 16 weeks of Lion’s Mane supplementation significantly improved cognitive scores, with a subsequent decline observed once supplementation ceased, emphasizing its role in maintaining functional neural connectivity [].4Cipriano Giovanni Luca (2026)Phytochemical and Fungal Bioactive Compounds in the “Brain Health Triad”: A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy
L-Theanine Stress Randomized Trial1 2 3 4 5 6 The global increase in life expectancy has led to a parallel rise in the prevalence of neurodegenerative diseases and age-related cognitive decline [,], establishing brain health as a paramount priority in contemporary biomedical research.4Cipriano Giovanni Luca (2026)Phytochemical and Fungal Bioactive Compounds in the “Brain Health Triad”: A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy
topicL-Theanine Stress Randomized Trial
claimEvidence regarding the acute effects of caffeine (CAF), L-theanine (TEA), and their combination remains inconsistent, particularly with respect to their combined influence on physical and cognitive performance in athletic populations.
evidence level2
citationTuncer SY (2026)
sourceAcute effects of combined and isolated caffeine and theanine supplementation on physical and cognitive performance in competitive athletes: a randomized, double-blind, placebo-controlled crossover study.
topicL-Theanine Stress Randomized Trial
claimResults Condition effects were found for leg strength ( p = 0.004, ηp 2 = 0.24) and back strength ( p = 0.008, ηp 2 = 0.19).
evidence level2
citationTuncer SY (2026)
sourceAcute effects of combined and isolated caffeine and theanine supplementation on physical and cognitive performance in competitive athletes: a randomized, double-blind, placebo-controlled crossover study.
topicL-Theanine Stress Randomized Trial
claimAdditionally, no significant difference was found between the conditions in aerobic endurance, maximum isometric handgrip strength, and hand-eye coordination results.
evidence level2
citationTuncer SY (2026)
sourceAcute effects of combined and isolated caffeine and theanine supplementation on physical and cognitive performance in competitive athletes: a randomized, double-blind, placebo-controlled crossover study.
topicL-Theanine Stress Randomized Trial
claimIntroduction Modern athletic performance is driven not only by physical capacity but also by rapid decision-making, attentional control, and visuomotor coordination.
evidence level2
citationTuncer SY (2026)
sourceAcute effects of combined and isolated caffeine and theanine supplementation on physical and cognitive performance in competitive athletes: a randomized, double-blind, placebo-controlled crossover study.
topicL-Theanine Stress Randomized Trial
claimUnder normal conditions, it is sequestered in the cytoplasm by Kelch-like ECH-associated protein 1 (Keap1), which targets it for degradation [].
evidence level4
citationCipriano Giovanni Luca (2026)
sourcePhytochemical and Fungal Bioactive Compounds in the “Brain Health Triad”: A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy
topicL-Theanine Stress Randomized Trial
claimThe following subsections provide a detailed analysis of the molecular profiles and clinical evidence for these three primary bioactives.
evidence level4
citationCipriano Giovanni Luca (2026)
sourcePhytochemical and Fungal Bioactive Compounds in the “Brain Health Triad”: A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy
topicL-Theanine Stress Randomized Trial
claimIn elderly patients with mild cognitive impairment (MCI), 16 weeks of Lion’s Mane supplementation significantly improved cognitive scores, with a subsequent decline observed once supplementation ceased, emphasizing its role in maintaining functional neural connectivity [].
evidence level4
citationCipriano Giovanni Luca (2026)
sourcePhytochemical and Fungal Bioactive Compounds in the “Brain Health Triad”: A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy
topicL-Theanine Stress Randomized Trial
claim1 2 3 4 5 6 The global increase in life expectancy has led to a parallel rise in the prevalence of neurodegenerative diseases and age-related cognitive decline [,], establishing brain health as a paramount priority in contemporary biomedical research.
evidence level4
citationCipriano Giovanni Luca (2026)
sourcePhytochemical and Fungal Bioactive Compounds in the “Brain Health Triad”: A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy

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Source documents

  1. Acute effects of combined and isolated caffeine and theanine supplementation on physical and cognitive performance in competitive athletes: a randomized, double-blind, placebo-controlled crossover study.
  2. Phytochemical and Fungal Bioactive Compounds in the “Brain Health Triad”: A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy