exercise performance

Is L-Lysine Exercise Recovery Randomized Trial safe?

Updated October 2026

Quick Answer

L-Lysine Exercise Recovery Randomized Trial has evidence relevant to safety, limits, and clinician-discussion contexts, but conclusions should stay close to the cited sources. One representative finding is: Plasma insulin concentrations increased following protein ingestion and were higher in the protein groups compared with PLA (time &#215; treatment effect:< 0.001).

Key Takeaways

  • 01Plasma insulin concentrations increased following protein ingestion and were higher in the protein groups compared with PLA (time &#215; treatment effect:< 0.001). [van Lieshout Glenn AA (2025)]
  • 02In contrast, when lysine was excluded from the EAAs, plasma EAA-Lys concentrations for HIGH-GLYC were slightly higher compared with LOW-GLYC between 90 and 120 min (&#8804; 0.018 for both timepoints,E), but this did not result in a different iAUC between the protein treatments over the full postprandial period (= 1.00,F). [van Lieshout Glenn AA (2025)]
  • 03As a result, peak lysine concentrations were 28% lower following ingestion of HIGH-GLYC compared with LOW-GLYC (191 &#177; 23 vs 266 &#177; 47 &#956;mol &#183; L, respectively,< 0.001). [van Lieshout Glenn AA (2025)]
  • 041 2 2 [3] [4] [5] [6] [7] [8] [9] 10 10 [11] [12] [13] 14 15 16 8 WHO Muscle is a highly adaptive organ that is constantly turning over, i.e., muscle proteins are continually synthesized and degraded. [van Lieshout Glenn AA (2025)]
The current Migaku evidence database contains 1 reusable source document for L-Lysine Exercise Recovery Randomized Trial. This answer focuses on safety, limits, and clinician-discussion contexts. - Plasma insulin concentrations increased following protein ingestion and were higher in the protein groups compared with PLA (time &#215; treatment effect:< 0.001). [van Lieshout Glenn AA (2025); evidence level 2] - In contrast, when lysine was excluded from the EAAs, plasma EAA-Lys concentrations for HIGH-GLYC were slightly higher compared with LOW-GLYC between 90 and 120 min (&#8804; 0.018 for both timepoints,E), but this did not result in a different iAUC between the protein treatments over the full postprandial period (= 1.00,F). [van Lieshout Glenn AA (2025); evidence level 2] - As a result, peak lysine concentrations were 28% lower following ingestion of HIGH-GLYC compared with LOW-GLYC (191 &#177; 23 vs 266 &#177; 47 &#956;mol &#183; L, respectively,< 0.001). [van Lieshout Glenn AA (2025); evidence level 2] - 1 2 2 [3] [4] [5] [6] [7] [8] [9] 10 10 [11] [12] [13] 14 15 16 8 WHO Muscle is a highly adaptive organ that is constantly turning over, i.e., muscle proteins are continually synthesized and degraded. [van Lieshout Glenn AA (2025); evidence level 2] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.

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DataL-Lysine Exercise Recovery Randomized Trial Evidence TableLegacy library material — check the original sources.DataLysine Exercise Recovery Randomized Trial Evidence TableLegacy library material — check the original sources.DataSulforaphane Exercise Recovery Randomized Trial Evidence TableLegacy library material — check the original sources.

Sources

  1. Milk Protein Glycation Compromises Postprandial Lysine Bioavailability but does not Modulate Postprandial Muscle Protein Synthesis Rates In Vivo in Males: A Double-blind, Randomized Parallel Trial &#9734;