Quick Answer
L-Citrulline Supplementation Exercise Performance Meta-Analysis has evidence relevant to strength of evidence and what the studies can or cannot prove, but conclusions should stay close to the cited sources. One representative finding is: These changes include endothelial dysfunction, reduced nitric oxide (NO) bioavailability, increased arterial stiffness, loss of skeletal muscle mass and strength, and unfavorable shifts in body composition (Cauley, Albu et al.).
Key Takeaways
- 01These changes include endothelial dysfunction, reduced nitric oxide (NO) bioavailability, increased arterial stiffness, loss of skeletal muscle mass and strength, and unfavorable shifts in body composition (Cauley, Albu et al.). [Chen Zhigang (2026)]
- 02From a vascular perspective, postmenopausal women frequently exhibit impaired endothelial-dependent vasodilation and increased central arterial stiffness, both of which contribute to exaggerated blood pressure responses during daily physical activity (Moreau and Hildreth). [Chen Zhigang (2026)]
- 03Reduced NO production, driven by diminished estrogen signaling and age-related endothelial dysfunction, plays a central role in these changes. [Chen Zhigang (2026)]
- 042023 2012 2013 2003 2014 2009 2008 Menopause is the permanent cessation of menstrual cycles, typically occurring around 45–55 years of age, marking the end of a woman’s reproductive period. [Chen Zhigang (2026)]
The current Migaku evidence database contains 2 reusable source documents for L-Citrulline Supplementation Exercise Performance Meta-Analysis. This answer focuses on strength of evidence and what the studies can or cannot prove.
- These changes include endothelial dysfunction, reduced nitric oxide (NO) bioavailability, increased arterial stiffness, loss of skeletal muscle mass and strength, and unfavorable shifts in body composition (Cauley, Albu et al.). [Chen Zhigang (2026); evidence level 3]
- From a vascular perspective, postmenopausal women frequently exhibit impaired endothelial-dependent vasodilation and increased central arterial stiffness, both of which contribute to exaggerated blood pressure responses during daily physical activity (Moreau and Hildreth). [Chen Zhigang (2026); evidence level 3]
- Reduced NO production, driven by diminished estrogen signaling and age-related endothelial dysfunction, plays a central role in these changes. [Chen Zhigang (2026); evidence level 3]
- 2023 2012 2013 2003 2014 2009 2008 Menopause is the permanent cessation of menstrual cycles, typically occurring around 45–55 years of age, marking the end of a woman’s reproductive period. [Chen Zhigang (2026); evidence level 3]
- 3 4 5 8 – 9 10 12 – 13 14 16 – 17 18 19 15 The decline in muscle mass in the human body is associated with diminished athletic performance and heightened susceptibility to falls and fractures, thereby compromising individuals’ ability to maintain a normal lifestyle. [Lv Xiaokang (2026); evidence level 3]
Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording.
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Sources