L-Citrulline Supplementation Exercise Performance Meta-Analysis Evidence Table

Structured evidence table for L-Citrulline Supplementation Exercise Performance Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
L-Citrulline Supplementation Exercise Performance Meta-AnalysisThese changes include endothelial dysfunction, reduced nitric oxide (NO) bioavailability, increased arterial stiffness, loss of skeletal muscle mass and strength, and unfavorable shifts in body composition (Cauley, Albu et al.).3Chen Zhigang (2026)L-citrulline as a nitric oxide–modulating therapeutic adjunct to exercise: effects on vascular function, arterial stiffness, and cardiometabolic health in postmenopausal and older women
L-Citrulline Supplementation Exercise Performance Meta-AnalysisFrom a vascular perspective, postmenopausal women frequently exhibit impaired endothelial-dependent vasodilation and increased central arterial stiffness, both of which contribute to exaggerated blood pressure responses during daily physical activity (Moreau and Hildreth).3Chen Zhigang (2026)L-citrulline as a nitric oxide–modulating therapeutic adjunct to exercise: effects on vascular function, arterial stiffness, and cardiometabolic health in postmenopausal and older women
L-Citrulline Supplementation Exercise Performance Meta-AnalysisReduced NO production, driven by diminished estrogen signaling and age-related endothelial dysfunction, plays a central role in these changes.3Chen Zhigang (2026)L-citrulline as a nitric oxide–modulating therapeutic adjunct to exercise: effects on vascular function, arterial stiffness, and cardiometabolic health in postmenopausal and older women
L-Citrulline Supplementation Exercise Performance Meta-Analysis2023 2012 2013 2003 2014 2009 2008 Menopause is the permanent cessation of menstrual cycles, typically occurring around 45–55 years of age, marking the end of a woman’s reproductive period.3Chen Zhigang (2026)L-citrulline as a nitric oxide–modulating therapeutic adjunct to exercise: effects on vascular function, arterial stiffness, and cardiometabolic health in postmenopausal and older women
L-Citrulline Supplementation Exercise Performance Meta-Analysis3 4 5 8 – 9 10 12 – 13 14 16 – 17 18 19 15 The decline in muscle mass in the human body is associated with diminished athletic performance and heightened susceptibility to falls and fractures, thereby compromising individuals’ ability to maintain a normal lifestyle.3Lv Xiaokang (2026)Potential role of L-citrulline in regulating exercise performance and muscle protein metabolism
L-Citrulline Supplementation Exercise Performance Meta-AnalysisFurthermore, many recent meta-analyses have highlighted the serious risks associated with this situation.3Lv Xiaokang (2026)Potential role of L-citrulline in regulating exercise performance and muscle protein metabolism
L-Citrulline Supplementation Exercise Performance Meta-AnalysisAging has been associated with increased sequestration of amino acids by the spleen and the development of sarcopenia.3Lv Xiaokang (2026)Potential role of L-citrulline in regulating exercise performance and muscle protein metabolism
L-Citrulline Supplementation Exercise Performance Meta-Analysis1 2 The regulation of muscle performance and protein turnover is a key focus in health research.3Lv Xiaokang (2026)Potential role of L-citrulline in regulating exercise performance and muscle protein metabolism
topicL-Citrulline Supplementation Exercise Performance Meta-Analysis
claimThese changes include endothelial dysfunction, reduced nitric oxide (NO) bioavailability, increased arterial stiffness, loss of skeletal muscle mass and strength, and unfavorable shifts in body composition (Cauley, Albu et al.).
evidence level3
citationChen Zhigang (2026)
sourceL-citrulline as a nitric oxide–modulating therapeutic adjunct to exercise: effects on vascular function, arterial stiffness, and cardiometabolic health in postmenopausal and older women
topicL-Citrulline Supplementation Exercise Performance Meta-Analysis
claimFrom a vascular perspective, postmenopausal women frequently exhibit impaired endothelial-dependent vasodilation and increased central arterial stiffness, both of which contribute to exaggerated blood pressure responses during daily physical activity (Moreau and Hildreth).
evidence level3
citationChen Zhigang (2026)
sourceL-citrulline as a nitric oxide–modulating therapeutic adjunct to exercise: effects on vascular function, arterial stiffness, and cardiometabolic health in postmenopausal and older women
topicL-Citrulline Supplementation Exercise Performance Meta-Analysis
claimReduced NO production, driven by diminished estrogen signaling and age-related endothelial dysfunction, plays a central role in these changes.
evidence level3
citationChen Zhigang (2026)
sourceL-citrulline as a nitric oxide–modulating therapeutic adjunct to exercise: effects on vascular function, arterial stiffness, and cardiometabolic health in postmenopausal and older women
topicL-Citrulline Supplementation Exercise Performance Meta-Analysis
claim2023 2012 2013 2003 2014 2009 2008 Menopause is the permanent cessation of menstrual cycles, typically occurring around 45–55 years of age, marking the end of a woman’s reproductive period.
evidence level3
citationChen Zhigang (2026)
sourceL-citrulline as a nitric oxide–modulating therapeutic adjunct to exercise: effects on vascular function, arterial stiffness, and cardiometabolic health in postmenopausal and older women
topicL-Citrulline Supplementation Exercise Performance Meta-Analysis
claim3 4 5 8 – 9 10 12 – 13 14 16 – 17 18 19 15 The decline in muscle mass in the human body is associated with diminished athletic performance and heightened susceptibility to falls and fractures, thereby compromising individuals’ ability to maintain a normal lifestyle.
evidence level3
citationLv Xiaokang (2026)
sourcePotential role of L-citrulline in regulating exercise performance and muscle protein metabolism
topicL-Citrulline Supplementation Exercise Performance Meta-Analysis
claimFurthermore, many recent meta-analyses have highlighted the serious risks associated with this situation.
evidence level3
citationLv Xiaokang (2026)
sourcePotential role of L-citrulline in regulating exercise performance and muscle protein metabolism
topicL-Citrulline Supplementation Exercise Performance Meta-Analysis
claimAging has been associated with increased sequestration of amino acids by the spleen and the development of sarcopenia.
evidence level3
citationLv Xiaokang (2026)
sourcePotential role of L-citrulline in regulating exercise performance and muscle protein metabolism
topicL-Citrulline Supplementation Exercise Performance Meta-Analysis
claim1 2 The regulation of muscle performance and protein turnover is a key focus in health research.
evidence level3
citationLv Xiaokang (2026)
sourcePotential role of L-citrulline in regulating exercise performance and muscle protein metabolism

Source documents

  1. L-citrulline as a nitric oxide–modulating therapeutic adjunct to exercise: effects on vascular function, arterial stiffness, and cardiometabolic health in postmenopausal and older women
  2. Potential role of L-citrulline in regulating exercise performance and muscle protein metabolism