Is Creatine and Resistance Training safe?

The current Migaku evidence database contains 4 reusable source documents for Creatine and Resistance Training. This answer focuses on safety, limits, and clinician-discussion contexts. - These studies have been removed, and the affected PRISMA flow diagram, study-characteristics table, risk-of-bias summary, outcome analyses, subgroup analyses, GRADE table, figures, and supplementary files have been updated accordingly. [Gu Jinfa (2026); evidence level 1] - Theandsections of the abstract have been corrected to read: This systematic review and meta-analysis pooled RCT evidence in healthy men aged 18–30 years old to quantify the effects of creatine supplementation in terms of body composition, maximal strength, and exercise performance. [Gu Jinfa (2026); evidence level 1] - Wingate peak and mean power both increased in both contexts (peak power +71.27 W; mean power +39.69 W), with no evidence that training context modified these results. [Gu Jinfa (2026); evidence level 1] - In the published article, two studies (Ostojic et al., 2004 and Percário et al., 2012) were inadvertently included despite having participants outside the prespecified eligible age range of 18–30 years. [Gu Jinfa (2026); evidence level 1] - Leg-press 1RM (k = 3; n = 111) improved with creatine: MD + 7.5 kg (95% CI + 2.2 to + 12.8; I² = 0%). [Naddafha S (2026); evidence level 1] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.