topicCreatine Sleep Deprivation Randomized Trial
claimIntroduction Insufficient sleep increases the risk of weight gain and metabolic dysfunction, while obesity is linked to disrupted sleep and metabolic impairment.
evidence level4
citationGood L (2026)
sourceBody-weight-specific and shared metabolomic responses to acute sleep loss in young adults.
topicCreatine Sleep Deprivation Randomized Trial
claimResults In response to TSD compared with NS, tryptophan levels increased (+12%, FDR Conclusions Acute sleep loss elicits both shared and body-weight-specific changes in circulating metabolites in young adults.
evidence level4
citationGood L (2026)
sourceBody-weight-specific and shared metabolomic responses to acute sleep loss in young adults.
topicCreatine Sleep Deprivation Randomized Trial
claimGiven that acute sleep loss is a common metabolic stressor that increases cardiometabolic risk, these differences may contribute to mechanistic hypotheses about the heightened vulnerability to metabolic dysregulation in individuals with obesity who are frequently exposed to sleep loss.
evidence level4
citationGood L (2026)
sourceBody-weight-specific and shared metabolomic responses to acute sleep loss in young adults.
topicCreatine Sleep Deprivation Randomized Trial
claimAlthough both conditions are tightly interconnected, it remains unclear whether body weight status determines how acute sleep loss alters metabolite levels.
evidence level4
citationGood L (2026)
sourceBody-weight-specific and shared metabolomic responses to acute sleep loss in young adults.
topicCreatine Sleep Deprivation Randomized Trial
claimThe present study investigates whether supplementation of a lower dose is associated with cognitive effects during sleep deprivation, focusing exclusively on cognitive performance outcomes.
evidence level4
citationGordji-Nejad A (2026)
sourceSingle-Dose Creatine Reduces Sleep Deprivation-Induced Deterioration in Cognitive Performance.
topicCreatine Sleep Deprivation Randomized Trial
claimConclusions: Our results show that a dose of 0.2 g/kg creatine is associated with a reduced deterioration in cognitive performance during sleep deprivation.
evidence level4
citationGordji-Nejad A (2026)
sourceSingle-Dose Creatine Reduces Sleep Deprivation-Induced Deterioration in Cognitive Performance.
topicCreatine Sleep Deprivation Randomized Trial
claimBackground/Objectives: Creatine is a supplement that, beyond its physiological effects, has been shown to have positive effects on cognitive abilities.
evidence level4
citationGordji-Nejad A (2026)
sourceSingle-Dose Creatine Reduces Sleep Deprivation-Induced Deterioration in Cognitive Performance.
topicCreatine Sleep Deprivation Randomized Trial
claimIn our previous study, we showed that a single dose of 0.35 g/kg creatine induces changes in brain metabolism during sleep deprivation and reduces deterioration in cognitive performance.
evidence level4
citationGordji-Nejad A (2026)
sourceSingle-Dose Creatine Reduces Sleep Deprivation-Induced Deterioration in Cognitive Performance.