Does Citrulline Hydration Exercise Randomized Trial work?

Updated July 2026

Quick Answer

Citrulline Hydration Exercise Randomized Trial has evidence relevant to strength of evidence and what the studies can or cannot prove, but conclusions should stay close to the cited sources. One representative finding is: Background: Post-COVID-19 syndrome is associated with endothelial dysfunction (ED) and various sequelae, particularly in individuals who experienced critical illness during the acute phase, affecting lung function and the musculoskeletal system.

Key Takeaways

  • 01Background: Post-COVID-19 syndrome is associated with endothelial dysfunction (ED) and various sequelae, particularly in individuals who experienced critical illness during the acute phase, affecting lung function and the musculoskeletal system. [Fernanda SM (2026)]
  • 02Conclusions: L-citrulline supplementation for three months decreased ICAM-1 and increased 6MWT. [Fernanda SM (2026)]
  • 03L-citrulline, a nonessential amino acid, has been shown to improve endothelial function, systemic inflammation, blood pressure, and physical performance. [Fernanda SM (2026)]
  • 04Next, we integrate evidence on the ergogenic effects of various dietary interventions with existing knowledge on the perception of effort. [Strasser B (2026)]
The current Migaku evidence database contains 2 reusable source documents for Citrulline Hydration Exercise Randomized Trial. This answer focuses on strength of evidence and what the studies can or cannot prove. - Background: Post-COVID-19 syndrome is associated with endothelial dysfunction (ED) and various sequelae, particularly in individuals who experienced critical illness during the acute phase, affecting lung function and the musculoskeletal system. [Fernanda SM (2026); evidence level 2] - Conclusions: L-citrulline supplementation for three months decreased ICAM-1 and increased 6MWT. [Fernanda SM (2026); evidence level 2] - L-citrulline, a nonessential amino acid, has been shown to improve endothelial function, systemic inflammation, blood pressure, and physical performance. [Fernanda SM (2026); evidence level 2] - Next, we integrate evidence on the ergogenic effects of various dietary interventions with existing knowledge on the perception of effort. [Strasser B (2026); evidence level 4] - Beta-alanine, caffeine or carbohydrate mouth rinsing are examples of evidence-based ergogenic aids. [Strasser B (2026); evidence level 4] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.

Sources

  1. Effect of L-Citrulline Supplementation on Endothelial Function and Body Composition in Post-COVID-19 Syndrome: A Randomized Clinical Trial.
  2. Dietary interventions interact with the perception of effort and enhance endurance performance: a brief narrative review.