Does Choline Cognition Meta-Analysis work?

The current Migaku evidence database contains 1 reusable source document for Choline Cognition Meta-Analysis. This answer focuses on strength of evidence and what the studies can or cannot prove. - Study design Following a pre-registered protocol (CRD42023403879), we searched MEDLINE, EMBASE, and PsycINFO for studies reporting 1H-MRS choline levels in individuals with psychosis, clinical high risk (CHR) states, and healthy controls. [Fanshawe JB (2026); evidence level 1] - Increased choline variability was observed in the dlPFC in psychosis cohorts and the mPFC and temporal lobe in CHR groups. [Fanshawe JB (2026); evidence level 1] - Increased variability in psychosis and greater differences in treatment-resistant cohorts suggest increased choline levels might identify a subgroup who do not respond to dopamine antagonist treatment. [Fanshawe JB (2026); evidence level 1] - Background and hypothesis Animal, post-mortem, and pharmacological studies suggest altered choline levels in psychosis. [Fanshawe JB (2026); evidence level 1] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.