What does the evidence say about Alpha Lipoic Acid Exercise Performance Randomized Trial?

The current Migaku evidence database contains 2 reusable source documents for Alpha Lipoic Acid Exercise Performance Randomized Trial. This answer focuses on benefits, uncertainty, and practical interpretation. - Background/Objectives : This study aimed to evaluate the effects of four weeks of combined Acetyl-l-Carnitine and alpha-lipoic acid (ALA) supplementation on anaerobic and aerobic performance and fatigue resistance in trained cyclists, hypothesizing improvements in maximal aerobic power (MAP), Wingate test performance, and reduced lactate accumulation. [de Rozas A (2025); evidence level 4] - Results : MAP increased by 3.4% (314 ± 32 W to 324 ± 37 W; p = 0.005) with no group interaction ( p = 0.457). [de Rozas A (2025); evidence level 4] - Methods : In a double-blind, randomized trial, 41 male trained cyclists (age: 36 ± 12 years; MAP: 4.35 ± 0.60 W·kg -1 ) were assigned to a supplement group (SUP, n = 19; 1200 mg/day Acetyl-l-Carnitine, 300 mg/day ALA, 1.1 mg Vitamin B1, 2.5 µg Vitamin B12) or placebo group (PLA, n = 22) for four weeks. [de Rozas A (2025); evidence level 4] - In addition to muscle damage and inflammation, intense training can cause oxidative stress due to increased radical formation of hydrogen peroxide (HO), superoxide (O), hypochlorous acid (HOCl) and nitric oxide (NO) []. [Isenmann Eduard (2020); evidence level 4] - In the following warm-up sets, the weight was increased by about 10–20% and the repetition number reduced to five and three repetitions. [Isenmann Eduard (2020); evidence level 4] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.