Citrulline Performance Meta-analysis: What the Evidence Says

Quick Answer

Citrulline Performance Meta-analysis has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are randomized trial, so conclusions should be framed as evidence-aware guidance rather than medical advice.

Key Takeaways

• This page is generated only from sources stored in the Migaku evidence knowledge base.
• Current evidence mix: 1 randomized trial, 1 preclinical study.
• Claims should be interpreted with the source type, study design, population, and publication date in mind.
• This article is educational and does not replace care from a qualified clinician.

Evidence Map

What The Sources Report

• For example, citrulline supplementation has been reported to improve cycling time-trial performance and oxygen uptake kinetics, while acute CM ingestion has also been associated with improved resistance exercise performance and reduced ratings of perceived exertion (RPE). [Yamanaka Ryo (2026); evidence level 2]
• For example, creatine-based supplementation has improved repeated sprint performance in some treadmill- and field-based protocols, whereas interventions targeting related nitric oxide pathways do not necessarily enhance anaerobic performance in trained athletes. [Yamanaka Ryo (2026); evidence level 2]
• Energy drink consumption has grown exponentially across adolescents, young adults, athletes, and shift workers, driven by demands for prolonged alertness and improved performance . [Muacevic Alexander (2026); evidence level 4]
• Because of heterogeneity in study designs, populations, dosing regimens, and outcome measures, no formal risk-of-bias tool or quantitative meta-analysis was applied. [Muacevic Alexander (2026); evidence level 4]

How To Read This Evidence

Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade.

Practical Interpretation

There is trial evidence in the current set, but population and intervention details still matter. For citrulline performance meta-analysis, the next editorial step is to add more targeted sources and separate strong findings from early or indirect evidence.

Limits Of This First Pass

This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review.

References

• Yamanaka Ryo (2026). Effects of Acute Citrulline Malate Supplementation on Repeated 100 m Sprint Performance in Trained Sprinters: A Randomized Crossover Study. DOI: 10.3390/sports14040143. PMCID: PMC13120297. PMID: 42043075. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC13120297/
• Muacevic Alexander (2026). Synergistic Actions of Natural Compounds for Enhancing Cognitive and Physical Performance: A Narrative Review. DOI: 10.7759/cureus.102674. PMCID: PMC12950988. PMID: 41777984. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC12950988/

Safety Note

Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.