topicZinc Cognition Randomized Trial
claimThe Cochrane Risk of Bias (ROB) 2.0 tool was used to assess the ROB in randomized controlled trials (RCTs).
evidence level1
citationHsiao YF (2026)
sourceThe Effects of Carnosine on Cognitive Function and Mental Health-A Systematic Review and Meta-Analysis.
topicZinc Cognition Randomized Trial
claimAdditionally, meta-analysis results showed that L-carnosine combined with anserine or antioxidant supplementation significantly improved the MMSE score compared to placebo (pooled net change = 0.62; 95% CI 0.23, 1.01), with small statistical heterogeneity ( I 2 = 21.3%).
evidence level1
citationHsiao YF (2026)
sourceThe Effects of Carnosine on Cognitive Function and Mental Health-A Systematic Review and Meta-Analysis.
topicZinc Cognition Randomized Trial
claimConclusions: A low strength of evidence suggests that L-carnosine supplement combined with anserine or antioxidants can slow cognitive function decline among healthy elderly or patients with probable Alzheimer's Disease or mild neurocognitive disorder.
evidence level1
citationHsiao YF (2026)
sourceThe Effects of Carnosine on Cognitive Function and Mental Health-A Systematic Review and Meta-Analysis.
topicZinc Cognition Randomized Trial
claimIntroduction: Previous research has shown that L-carnosine (β-alanyl-L-histidine) can reduce cognitive decline and improve mental health outcomes, but an updated systematic review of the effects of carnosine alone or in combination with other supplemental nutrients or bioactive compounds on these interconnected outcomes is lacking.
evidence level1
citationHsiao YF (2026)
sourceThe Effects of Carnosine on Cognitive Function and Mental Health-A Systematic Review and Meta-Analysis.
topicZinc Cognition Randomized Trial
claimThis review synthesizes current evidence on the effects of both plant- and animal-derived foods on cognitive outcomes from early development through older adulthood.
evidence level4
citationHardaway C (2026)
sourceBrain Foods: A Narrative Review of Food Items and Their Impact on Cognition over the Life Course.
topicZinc Cognition Randomized Trial
claimEvidence was evaluated across life stages, considering nutrient bioavailability, dietary patterns, and the interplay between structural, socioeconomic, and environmental factors that influence access to these foods.
evidence level4
citationHardaway C (2026)
sourceBrain Foods: A Narrative Review of Food Items and Their Impact on Cognition over the Life Course.
topicZinc Cognition Randomized Trial
claimIn early childhood, eggs, meat, and nuts were linked to improved neurodevelopment and reductions in developmental delays, while evidence for seafood and dairy was more mixed.
evidence level4
citationHardaway C (2026)
sourceBrain Foods: A Narrative Review of Food Items and Their Impact on Cognition over the Life Course.
topicZinc Cognition Randomized Trial
claimBackground/Objectives : Cognitive function is fundamental to daily life, and nutrition is a key modifiable determinant of brain health across the lifespan.
evidence level4
citationHardaway C (2026)
sourceBrain Foods: A Narrative Review of Food Items and Their Impact on Cognition over the Life Course.