topicZinc Acne Randomized Trial
claimThese treatments show varying degrees of efficacy and improved safety profiles, but most lack head-to-head comparisons with isotretinoin.
evidence level4
citationTommasino N (2026)
sourceBeyond Isotretinoin: A Narrative Review of Emerging Systemic Therapies for Moderate-to-Severe Acne.
topicZinc Acne Randomized Trial
claimConclusion Several systemic options beyond isotretinoin have emerged, showing potential in specific subgroups or as adjunctive therapies.
evidence level4
citationTommasino N (2026)
sourceBeyond Isotretinoin: A Narrative Review of Emerging Systemic Therapies for Moderate-to-Severe Acne.
topicZinc Acne Randomized Trial
claimHowever, further large-scale comparative studies are needed to define their roles within evidence-based acne management algorithms.
evidence level4
citationTommasino N (2026)
sourceBeyond Isotretinoin: A Narrative Review of Emerging Systemic Therapies for Moderate-to-Severe Acne.
topicZinc Acne Randomized Trial
claimBackground Acne vulgaris is a common inflammatory skin disorder with significant psychosocial impact.
evidence level4
citationTommasino N (2026)
sourceBeyond Isotretinoin: A Narrative Review of Emerging Systemic Therapies for Moderate-to-Severe Acne.