Structured evidence table for Vitamin K2 Bone Markers Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Vitamin K2 Bone Markers Randomized Trial | Background Osteoporosis is a metabolic bone disease characterized by decreased bone mass and increased fracture risk. | 1 | Zhang Z (2025) | The effect of vitamin K2 supplementation on bone turnover biochemical markers in postmenopausal osteoporosis patients: a systematic review and meta-analysis. |
| Vitamin K2 Bone Markers Randomized Trial | Vitamin K2 (VK2) increased osteocalcin (OC; MD 1.86, 95% CI 1.17-2.56) and bone-specific alkaline phosphatase (BAP; MD 1.49, 95% CI 0.98-2.00). | 1 | Zhang Z (2025) | The effect of vitamin K2 supplementation on bone turnover biochemical markers in postmenopausal osteoporosis patients: a systematic review and meta-analysis. |
| Vitamin K2 Bone Markers Randomized Trial | It reduced undercarboxylated OC (ucOC; WMD -1.54, 95% CI -2.44 to -0.64) and tartrate-resistant acid phosphatase (TRAP; MD -0.83, 95% CI -1.21 to -0.46). | 1 | Zhang Z (2025) | The effect of vitamin K2 supplementation on bone turnover biochemical markers in postmenopausal osteoporosis patients: a systematic review and meta-analysis. |
| Vitamin K2 Bone Markers Randomized Trial | Bone turnover markers, such as osteocalcin (OC), undercarboxylated osteocalcin (ucOC), and other biochemical indicators, are important for assessing bone metabolism. | 1 | Zhang Z (2025) | The effect of vitamin K2 supplementation on bone turnover biochemical markers in postmenopausal osteoporosis patients: a systematic review and meta-analysis. |
| Vitamin K2 Bone Markers Randomized Trial | Conclusions : These findings identify vitamin K-dependent carboxylation as a mechanistically specific and modifiable factor associated with skeletal fragility beyond bone mineral density, with distinct skeletal consequences across osteocalcin carboxylation states. | 4 | Sharma DK (2026) | Vitamin K Status and Skeletal Fragility: Differential Associations of Osteocalcin Carboxylation States with Bone Strength, Geometry and Microarchitecture. |
| Vitamin K2 Bone Markers Randomized Trial | Background: The contribution of specific nutritional biomarkers to skeletal fragility remains poorly understood, in part because most studies include participants with metabolic conditions that obscure nutrient-specific effects. | 4 | Sharma DK (2026) | Vitamin K Status and Skeletal Fragility: Differential Associations of Osteocalcin Carboxylation States with Bone Strength, Geometry and Microarchitecture. |
| Vitamin K2 Bone Markers Randomized Trial | We aimed to examine incremental contribution of six pathway-specific nutritional biomarkers. | 4 | Sharma DK (2026) | Vitamin K Status and Skeletal Fragility: Differential Associations of Osteocalcin Carboxylation States with Bone Strength, Geometry and Microarchitecture. |
Source documents