topicVitamin K1 Bone Health Meta-Analysis
claimConclusion The data from this post-hoc analysis do not provide evidence for the assumption that vitamin K status modifies or enhances effects of vitamin D supplementation on cardiovascular or bone parameters.
evidence level2
citationTheiler-Schwetz V (2026)
sourceVitamin K status has no influence on the effect of vitamin D supplementation on bone turnover and cardiovascular markers: a randomized controlled trial.
topicVitamin K1 Bone Health Meta-Analysis
claimThese findings are in line with current guidelines, which do not routinely recommend vitamin K and D co-treatment in patients with osteoporosis.
evidence level2
citationTheiler-Schwetz V (2026)
sourceVitamin K status has no influence on the effect of vitamin D supplementation on bone turnover and cardiovascular markers: a randomized controlled trial.
topicVitamin K1 Bone Health Meta-Analysis
claimBackground/objectives Vitamin K and D co-treatment may have additive effects on bone and cardiovascular health and is frequently used as an over-the-counter supplement.
evidence level2
citationTheiler-Schwetz V (2026)
sourceVitamin K status has no influence on the effect of vitamin D supplementation on bone turnover and cardiovascular markers: a randomized controlled trial.
topicVitamin K1 Bone Health Meta-Analysis
claimThe primary aim of this study was to assess whether the effect of vitamin D supplementation on bone turnover markers and cardiovascular parameters is modified according to vitamin K status at baseline (i.e., serum levels of vitamin K1, MK4 and MK7).
evidence level2
citationTheiler-Schwetz V (2026)
sourceVitamin K status has no influence on the effect of vitamin D supplementation on bone turnover and cardiovascular markers: a randomized controlled trial.